PMID- 21593803
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20220408
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 19
IP  - 8
DP  - 2011 Aug
TI  - Amelioration of lipid abnormalities by alpha-lipoic acid through antioxidative and 
      anti-inflammatory effects.
PG  - 1647-53
LID - 10.1038/oby.2011.121 [doi]
AB  - Recent data have revealed that oxidative products and inflammatory mediators are 
      increased in the insulin-resistant states of obesity and type 2 diabetes mellitus 
      (T2DM). Obese patients with impaired glucose tolerance (IGT) are at high risk for 
      developing T2DM and have high incidence of dyslipidemia. alpha-Lipoic acid (ALA) is a 
      potent antioxidant with insulin sensitizing activity. However, it is not clear 
      whether ALA is effective on lipid parameters in humans. This study has 
      investigated 22 obese subjects with IGT (obese-IGT), 13 of whom underwent 2-week 
      ALA treatment, 600 mg intravenously once daily. Before and after the treatment, 
      euglycemic-hyperinsulinemic clamps were used to measure insulin sensitivity. 
      Meanwhile, plasma lipids, oxidative products, and chronic inflammatory markers 
      were measured. After treatment of ALA in obese-IGT patients, insulin sensitivity 
      was improved, insulin sensitivity index (ISI) impressively enhanced by 41%. 
      Plasma levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol 
      (T-Chol), low density lipoprotein-cholesterol (LDL-Chol), small dense LDL-Chol 
      (sd-LDL), oxidized LDL-Chol (ox-LDL-Chol), very low density 
      lipoprotein-cholesterol (VLDL-Chol) were all significantly decreased (P < 0.01). 
      At the same time, both plasma oxidative products (malondialdehyde (MDA), 
      8-iso-prostaglandin) and inflammatory markers (tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-6 (IL-6)) were remarkably decreased (P < 0.01), while adiponectin was 
      increased (P < 0.01). There are significant negative correlations between ISI and 
      plasma FFAs, sd-LDL-Chol, ox-LDL-Chol, MDA, 8-iso-prostaglandin, TNF-alpha, and IL-6, 
      and positive correlations with HDL-Chol and adiponectin in obese-IGT patients. 
      The results indicate that short-term treatment with ALA can improve insulin 
      sensitivity and plasma lipid profile possibly through amelioration of oxidative 
      stress and chronic inflammatory reaction in obese patients with IGT.
FAU - Zhang, Yongyan
AU  - Zhang Y
AD  - Department of Endocrinology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Han, Ping
AU  - Han P
FAU - Wu, Na
AU  - Wu N
FAU - He, Bing
AU  - He B
FAU - Lu, Yan
AU  - Lu Y
FAU - Li, Shuwen
AU  - Li S
FAU - Liu, Yang
AU  - Liu Y
FAU - Zhao, Sheng
AU  - Zhao S
FAU - Liu, Letong
AU  - Liu L
FAU - Li, Yan
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110519
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Adiponectin)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipids)
RN  - 0 (Prostaglandins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 73Y7P0K73Y (Thioctic Acid)
SB  - IM
MH  - Adiponectin/blood
MH  - Adult
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Antioxidants/pharmacology/*therapeutic use
MH  - Biomarkers/blood
MH  - Glucose Intolerance/blood/complications/*drug therapy
MH  - Humans
MH  - *Insulin Resistance
MH  - Interleukin-6/blood
MH  - Lipids/*blood
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Obesity/blood/complications/*drug therapy
MH  - Oxidative Stress/drug effects
MH  - Prostaglandins/blood
MH  - Thioctic Acid/pharmacology/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2011/05/20 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - oby2011121 [pii]
AID - 10.1038/oby.2011.121 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2011 Aug;19(8):1647-53. doi: 10.1038/oby.2011.121. Epub 
      2011 May 19.