PMID- 21594411
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190606
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 3
IP  - 3
DP  - 1996 May
TI  - Regulation of expression of the hepatocyte growth factor scatter factor receptor, 
      c-met, by cytokines.
PG  - 553-7
AB  - The c-met proto-oncogene product is a 190 kDa heterodimeric receptor tyrosine 
      kinase activated by the binding of its li,gand, hepatocyte growth factor/scatter 
      factor (HGF/SF), a cytokine known to stimulate cell growth, motility and 
      morphogenesis. Altered expression of c-met receptor levels in tumour cells may 
      therefore play an important role in regulating the metastatic progression of 
      cancers. We have determined the effects of a number of cytokines on c-met 
      expression in the colon cancer cell line HT29. We report that c-met message and 
      protein levels are up-regulated by the cytokines IL-5, IL-10, TGF-beta, PDGF and 
      basic FCF while down-regulation occurred after treatment with IFN-gamma. We 
      conclude that up-regulation of the HGF/SF receptor in vivo by the above cytokines 
      may enhance tumour cell sensitivity to HGF/SF and therefore be an important step 
      in the progression of metastatic spread.
FAU - Hiscox, S
AU  - Hiscox S
FAU - Jiang, W
AU  - Jiang W
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
AID - 10.3892/or.3.3.553 [doi]
PST - ppublish
SO  - Oncol Rep. 1996 May;3(3):553-7. doi: 10.3892/or.3.3.553.