PMID- 21594459
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190606
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 3
IP  - 5
DP  - 1996 Sep
TI  - Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion 
      kinase (FAK) and paxillin and enhances cell-matrix interactions.
PG  - 819-23
AB  - This study examined the effects of hepatocyte growth factor/scatter factor 
      (HGF/SF) on the adhesion of HT115 (human colon) and MDA MB 231 (human breast) 
      tumour cells to an extracellular matrix, Matrigel, together with the tyrosine 
      phosphorylation of focal adhesion kinase (FAK) and paxillin. Treatment of cells 
      with HGF increased cell adhesion to matrix. Following adhesion to Matrigel, FAK 
      and paxillin were quickly phosphorylated and located to the focal adhesion area. 
      HGF/SF increased both tyrosine phosphorylation of FAK and paxillin and also 
      increased formation of focal adhesion. HGF also induced an increased spreading on 
      matrix. It is concluded therefore that HGF/SF stimulated FAK and paxillin 
      phosphorylation resulting in an increased tumour-matrix adhesion.
FAU - Jiang, W
AU  - Jiang W
AD  - OSAKA UNIV,SCH MED,DEPT ONCOL,BIOMED RES CTR,SUITA,OSAKA 565,JAPAN.
FAU - Hiscox, S
AU  - Hiscox S
FAU - Nakamura, T
AU  - Nakamura T
FAU - Hallett, M
AU  - Hallett M
FAU - Puntis, M
AU  - Puntis M
FAU - Mansel, R
AU  - Mansel R
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
AID - 10.3892/or.3.5.819 [doi]
PST - ppublish
SO  - Oncol Rep. 1996 Sep;3(5):819-23. doi: 10.3892/or.3.5.819.