PMID- 21594461 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20190606 IS - 1021-335X (Print) IS - 1021-335X (Linking) VI - 3 IP - 5 DP - 1996 Sep TI - Improved detection of chromosome 16 rearrangements in acute myeloid leukemias using 16p and 16q specific microdissection DNA libraries. PG - 829-32 AB - DNA libraries of the human chromosome arms 16p and 16q have been constructed by means of microdissection for the use of fluorescence in situ hybridization (FISH) analysis of rearranged chromosome 16 in acute myeloid leukemia. FISH with differently labeled chromosome 16p and 16q arm-specific libraries on normal metaphase spreads resulted in bright painting signals on both arms of chromosome 16, each stained in a different color. Hybridization on bone marrow samples of acute leukemia patients having a pericentric inversion of chromosome 16 showed on one chromosome 16 the presence of q-arm specific material on the p-arm adjacent to the centromere and vice versa, resulting in an alternating red-green-red-green colored chromosome pattern in the FISH analysis. FAU - Chudoba, I AU - Chudoba I AD - RUSSIAN ACAD SCI,INST CYTOL & GENET,NOVOSIBIRSK 630090,RUSSIA. FAU - Rubtsov, N AU - Rubtsov N FAU - Senger, G AU - Senger G FAU - Junker, K AU - Junker K FAU - Bleck, C AU - Bleck C FAU - Claussen, U AU - Claussen U LA - eng PT - Journal Article PL - Greece TA - Oncol Rep JT - Oncology reports JID - 9422756 EDAT- 1996/09/01 00:00 MHDA- 1996/09/01 00:01 CRDT- 2011/05/20 06:00 PHST- 2011/05/20 06:00 [entrez] PHST- 1996/09/01 00:00 [pubmed] PHST- 1996/09/01 00:01 [medline] AID - 10.3892/or.3.5.829 [doi] PST - ppublish SO - Oncol Rep. 1996 Sep;3(5):829-32. doi: 10.3892/or.3.5.829.