PMID- 21595294
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20190918
IS  - 0009-918X (Print)
IS  - 0009-918X (Linking)
VI  - 51
IP  - 4
DP  - 2011 Apr
TI  - [Anti-aquaporin-4 antibody autoimmune syndrome with disturbance of consciousness, 
      respiratory failure, and ophthalmoplegia associated with extensive brain stem 
      involvement with intractable hiccup and nausea as an initial manifestation. A 
      case report].
PG  - 255-60
AB  - A 45-year-old female was positive for anti-aquaporin-4 antibody with disturbance 
      of consciousness, respiratory failure, and ophthalmoplegia associated with 
      extensive brain stem involvement with intractable hiccup and nausea as an initial 
      manifestation. Her level of consciousness and state of respiration worsened 
      approximately one month later. There was no abnormality in the cerebrospinal 
      fluid examination. A lesion was found in the medullary tegmentum on brain MRI. 
      The patient received steroid pulse therapy and her level of consciousness 
      improved the next day. However, her state of respiration worsened, and she had 
      extensively clinical involvement of the brain stem. Her symptoms gradually 
      improved with intravenous administration of prednisolone and intravenous 
      immunoglobulin therapy (IVIg). The patient had almost completely recovered, but 
      she relapsed with cervical myelitis extending over 3 vertebral segments 
      approximately 10 months later. She underwent steroid pulse therapy, oral 
      prednisolone, and IVIg again and improved.
FAU - Kai, Toru
AU  - Kai T
AD  - Department of Neurology, Imakiire General Hospital.
FAU - Tajima, Seiichiro
AU  - Tajima S
FAU - Arata, Hitoshi
AU  - Arata H
FAU - Hayashi, Shigeaki
AU  - Hayashi S
FAU - Nagado, Tatsui
AU  - Nagado T
FAU - Maruyama, Yoshikazu
AU  - Maruyama Y
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
RN  - 0 (AQP4 protein, human)
RN  - 0 (Aquaporin 4)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Aquaporin 4/*immunology
MH  - Autoimmune Diseases/*drug therapy
MH  - Brain Stem/*pathology
MH  - Consciousness Disorders/*drug therapy
MH  - Female
MH  - Hiccup/drug therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage
MH  - Methylprednisolone/administration & dosage
MH  - Middle Aged
MH  - Nausea/drug therapy
MH  - Ophthalmoplegia/*drug therapy
MH  - Prednisolone/administration & dosage
MH  - Pulse Therapy, Drug
MH  - Respiratory Insufficiency/*drug therapy
MH  - Syndrome
MH  - Treatment Outcome
EDAT- 2011/05/21 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - 10.5692/clinicalneurol.51.255 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2011 Apr;51(4):255-60. doi: 10.5692/clinicalneurol.51.255.