PMID- 2159541
OWN - NLM
STAT- MEDLINE
DCOM- 19900614
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 64
IP  - 6
DP  - 1990 Jun
TI  - In vitro susceptibility of T lymphocytes from chimpanzees (Pan troglodytes) to 
      human herpesvirus 6 (HHV-6): a potential animal model to study the interaction 
      between HHV-6 and human immunodeficiency virus type 1 in vivo.
PG  - 2751-8
AB  - The in vitro susceptibility of several nonhuman primate species to human 
      herpesvirus 6 (HHV-6) was investigated. Only peripheral blood mononuclear cells 
      from chimpanzees (Pan troglodytes) were found permissive to productive infection 
      by HHV-6, indicating that the host range of HHV-6, albeit limited, may not be 
      restricted to Homo sapiens. However, natural HHV-6 infection in chimpanzees, as 
      well as in the other species tested, could not be documented by serological 
      analysis. As previously observed with human cells, HHV-6 infection of chimpanzee 
      peripheral blood mononuclear cells was highly cytopathic and the infected cells 
      exhibited phenotypic features of activated T lymphocytes. Although in humans the 
      majority of HHV-6-infected lymphocytes displayed the CD4 antigen, in chimpanzees 
      a mixed CD4+ and CD8+ phenotype was observed. HHV-6 was also shown to 
      productively coinfect individual chimpanzee T cells with human immunodeficiency 
      virus type 1, resulting in an accelerated induction of cytopathicity. In light of 
      these findings, we propose the utilization of chimpanzees as a potential animal 
      model system to investigate the in vivo interaction between HHV-6 and human 
      immunodeficiency virus type 1 and its relevance to the development of acquired 
      immune deficiency syndrome.
FAU - Lusso, P
AU  - Lusso P
AD  - Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes 
      of Health, Bethesda, Maryland 20892.
FAU - Markham, P D
AU  - Markham PD
FAU - DeRocco, S E
AU  - DeRocco SE
FAU - Gallo, R C
AU  - Gallo RC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Surface)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Antigens, Surface/analysis
MH  - Cells, Cultured
MH  - Disease Susceptibility
MH  - Fluorescent Antibody Technique
MH  - HIV-1/*pathogenicity
MH  - Herpesvirus 6, Human/*pathogenicity/ultrastructure
MH  - Humans
MH  - Microscopy, Electron
MH  - Models, Biological
MH  - Pan troglodytes/*microbiology
MH  - Primates/microbiology
MH  - Species Specificity
MH  - T-Lymphocytes/immunology/*microbiology/ultrastructure
PMC - PMC249455
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
PMCR- 1990/06/01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
PHST- 1990/06/01 00:00 [pmc-release]
AID - 10.1128/JVI.64.6.2751-2758.1990 [doi]
PST - ppublish
SO  - J Virol. 1990 Jun;64(6):2751-8. doi: 10.1128/JVI.64.6.2751-2758.1990.