PMID- 21595698
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20211020
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Print)
IS  - 0022-1198 (Linking)
VI  - 56
IP  - 5
DP  - 2011 Sep
TI  - Axonal injury in young pediatric head trauma: a comparison study of beta-amyloid 
      precursor protein (beta-APP) immunohistochemical staining in traumatic and 
      nontraumatic deaths.
PG  - 1198-205
LID - 10.1111/j.1556-4029.2011.01814.x [doi]
AB  - We tested the independent utility of beta-amyloid precursor protein (beta-APP) 
      immunohistochemical staining as evidence of brain trauma in the deaths of young 
      children. Blinded reviewers retrospectively reviewed immunostained brain tissues 
      from homicidal deaths, age-matched control cases without evidence of trauma, as 
      well as cases of sudden infant death syndrome (SIDS). The reviewers correctly 
      identified five of the seven cases with documented inflicted head trauma. 
      However, one of seven age-matched control cases and one of 10 SIDS/sudden 
      unexplained death in infancy (SUDI) cases demonstrated staining patterns similar 
      to those seen in cases of inflicted trauma. We discuss these cases and the 
      circumstances surrounding them with the intent to explain the difficulties 
      associated with immunohistological interpretation of axonal injury. Although the 
      utility of beta-APP is quite powerful if not confounded by global hypoxic-ischemic 
      injury, ultimately, beta-APP studies should be only one piece of information in the 
      determination of cause and manner of death.
CI  - (c) 2011 American Academy of Forensic Sciences.
FAU - Johnson, Michael W
AU  - Johnson MW
AD  - Office of Chief Medical Examiner (OCME), Urban County Government Center, 
      Louisville, KY, USA.
FAU - Stoll, Lisa
AU  - Stoll L
FAU - Rubio, Ana
AU  - Rubio A
FAU - Troncoso, Juan
AU  - Troncoso J
FAU - Pletnikova, Olga
AU  - Pletnikova O
FAU - Fowler, David R
AU  - Fowler DR
FAU - Li, Ling
AU  - Li L
LA  - eng
GR  - P01 AG004953/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20110519
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Axons/*metabolism/pathology
MH  - Brain/*metabolism/*pathology
MH  - Cardiopulmonary Resuscitation
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Coroners and Medical Examiners
MH  - Craniocerebral Trauma/*metabolism
MH  - Cytoplasm/metabolism/pathology
MH  - Female
MH  - Forensic Pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Neurons/metabolism/pathology
MH  - Retrospective Studies
MH  - Staining and Labeling
MH  - Sudden Infant Death/pathology
PMC - PMC4033609
MID - NIHMS584202
EDAT- 2011/05/21 06:00
MHDA- 2012/04/06 06:00
PMCR- 2014/05/26
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PHST- 2014/05/26 00:00 [pmc-release]
AID - 10.1111/j.1556-4029.2011.01814.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2011 Sep;56(5):1198-205. doi: 10.1111/j.1556-4029.2011.01814.x. 
      Epub 2011 May 19.