PMID- 21595834
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20110727
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 8
IP  - 8
DP  - 2011 Aug
TI  - Cross-sex hormone therapy alters the serum lipid profile: a retrospective cohort 
      study in 169 transsexuals.
PG  - 2361-9
LID - 10.1111/j.1743-6109.2011.02311.x [doi]
AB  - INTRODUCTION: Cross-sex hormone therapy (CSHT) is known to lead to alterations in 
      the serum lipid profile. However, the available reports in the literature are 
      problematic, because of methodological limitations. AIMS: To assess changes in 
      the fasting serum lipid profile during CSHT, including long-term follow-up. 
      METHODS: Retrospective chart analysis of all 89 male-to-female (MtF) and 80 
      female-to-male (FtM) transsexuals who underwent standard CSHT at the Department 
      of Gynecologic Endocrinology of the Medical University of Vienna (university 
      hospital, tertiary care center), from 1995 to 2009. MAIN OUTCOME MEASURES: The 
      results of the lipid profile were analyzed, including triglycerides (TG), total 
      cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), 
      and the TC-to-HDL ratio, at the time of treatment initiation (time point "0") and 
      at 3, 12, 24, and 60 months after the start of CSHT. RESULTS: The mean age of 
      patients about to commence CSHT was 35.7 +/- 11.4 years (MtF) and 26.0 +/- 6.3 years 
      (FtM). For MtF transsexuals, consistent follow-up for 24 and 60 months was 
      available in 83 (93.3%) and 58 (65.2%) patients, respectively; for FtM 
      transsexuals, follow-up was available in 57 (71.3%) and 39 (48.8%) patients, 
      respectively. When testing for an association between the lipid parameters and 
      the time after treatment initiation, significant increases for TG (P < 0.001), TC 
      (P = 0.021), and HDL (P = 0.001) were found for MtF transsexuals, whereas TG, TC, 
      and LDL (P < 0.001) increased and HDL (P < 0.001) decreased in FtM patients. 
      CONCLUSION: Both MtF and FtM transsexuals experience alterations in the serum 
      lipid profile because of CSHT, with the changes in FtM patients possibly more 
      relevant in terms of atherogenesis.
CI  - (c) 2011 International Society for Sexual Medicine.
FAU - Ott, Johannes
AU  - Ott J
AD  - Department of Gynecologic Endocrinology and Reproductive Medicine-Medical 
      University of Vienna, Vienna, Austria. johannes.ott@meduniwien.ac.at
FAU - Aust, Stefanie
AU  - Aust S
FAU - Promberger, Regina
AU  - Promberger R
FAU - Huber, Johannes C
AU  - Huber JC
FAU - Kaufmann, Ulrike
AU  - Kaufmann U
LA  - eng
PT  - Journal Article
DEP - 20110519
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Gonadal Steroid Hormones/*pharmacology
MH  - Humans
MH  - Lipid Metabolism/*drug effects
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Sex Reassignment Procedures
MH  - Transsexualism/*drug therapy
MH  - Young Adult
EDAT- 2011/05/21 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - S1743-6095(15)33610-9 [pii]
AID - 10.1111/j.1743-6109.2011.02311.x [doi]
PST - ppublish
SO  - J Sex Med. 2011 Aug;8(8):2361-9. doi: 10.1111/j.1743-6109.2011.02311.x. Epub 2011 
      May 19.