PMID- 21595962
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20211020
IS  - 1752-0509 (Electronic)
IS  - 1752-0509 (Linking)
VI  - 5
DP  - 2011 May 19
TI  - A general life history theory for effects of caloric restriction on health 
      maintenance.
PG  - 78
LID - 10.1186/1752-0509-5-78 [doi]
AB  - BACKGROUND: Caloric restriction (CR) has been shown to keep organisms in a 
      relatively youthful and healthy state compared to ad libitum fed counterparts, as 
      well as to extend the lifespan of a diverse set of organisms. Several attempts 
      have been made to understand the underlying mechanisms from the viewpoint of 
      energy tradeoffs in organisms' life histories. However, most models are based on 
      assumptions which are difficult to justify, or are endowed with free-adjusting 
      parameters whose biological relevancy is unclear. RESULTS: In this paper, we 
      derive a general quantitative, predictive model based on physiological data for 
      endotherms. We test the hypothesis that an animal's state of health is correlated 
      with biological mechanisms responsible for the maintenance of that animal's 
      functional integrities. Such mechanisms require energy. By suppressing animals' 
      caloric energy supply and biomass synthesis, CR alters animals' energy allocation 
      strategies and channels additional energy to those maintenance mechanisms, 
      therefore enhancing their performance. Our model corroborates the observation 
      that CR's effects on health maintenance are positively correlated with the degree 
      and duration of CR. Furthermore, our model shows that CR's effects on health 
      maintenance are negatively correlated to the temperature drop observed in 
      endothermic animals, and is positively correlated to animals' body masses. These 
      predictions can be tested by further experimental research. CONCLUSION: Our model 
      reveals how animals will alter their energy budget when food availability is low, 
      and offers better understanding of the tradeoffs between growth and somatic 
      maintenance; therefore shedding new light on aging research from an energetic 
      viewpoint.
FAU - Hou, Chen
AU  - Hou C
AD  - Department of Systems and Computational Biology, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA. houc75@gmail.com
FAU - Bolt, Kendra
AU  - Bolt K
FAU - Bergman, Aviv
AU  - Bergman A
LA  - eng
GR  - P01-AG027734/AG/NIA NIH HHS/United States
GR  - R01-AG028872/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110519
PL  - England
TA  - BMC Syst Biol
JT  - BMC systems biology
JID - 101301827
SB  - IM
MH  - Aging
MH  - Animals
MH  - Body Temperature
MH  - *Caloric Restriction
MH  - Energy Intake
MH  - Energy Metabolism/physiology
MH  - Life
MH  - Longevity/physiology
MH  - Models, Biological
MH  - Rats
MH  - *Systems Biology
PMC - PMC3123202
EDAT- 2011/05/21 06:00
MHDA- 2011/10/04 06:00
PMCR- 2011/05/19
CRDT- 2011/05/21 06:00
PHST- 2011/02/07 00:00 [received]
PHST- 2011/05/19 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
PHST- 2011/05/19 00:00 [pmc-release]
AID - 1752-0509-5-78 [pii]
AID - 10.1186/1752-0509-5-78 [doi]
PST - epublish
SO  - BMC Syst Biol. 2011 May 19;5:78. doi: 10.1186/1752-0509-5-78.