PMID- 21596493
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20131121
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 118
IP  - 2-3
DP  - 2011 Nov 1
TI  - Effects of group exposure on single injection-induced behavioral sensitization to 
      drugs of abuse in mice.
PG  - 349-59
LID - 10.1016/j.drugalcdep.2011.04.017 [doi]
AB  - BACKGROUND: Behavioral sensitization in rodents is hypothesized to reflect 
      neuronal adaptations that are related to drug addiction in humans. We evaluated 
      the effects of group exposure on the acute hyperlocomotion and behavioral 
      sensitization induced by four drugs of abuse in C57BL/6 mice: 
      methylenedioxymethamphetamine (MDMA), d-amphetamine, morphine and ethanol. 
      METHODS: In the priming session, animals received an ip injection of one of the 
      drugs of abuse and were exposed to an open field either individually or in groups 
      of four. Seven days later, we assessed behavioral sensitization in the challenge 
      session. All animals received an ip injection of the same drug and were exposed 
      to the open field in the same social conditions described for the priming 
      session. Locomotion and social interaction were quantified during each session. 
      RESULTS: Acute MDMA, morphine and ethanol, but not d-amphetamine, increased 
      social interaction. However, group exposure only potentiated MDMA-induced 
      hyperlocomotion. After a challenge injection of each drug, there was no 
      sensitization to the facilitating effect of MDMA, morphine or ethanol on social 
      interaction, but locomotion sensitization developed to all drugs of abuse except 
      ethanol. This sensitization was potentiated by group exposure in MDMA-treated 
      animals, attenuated in morphine-treated animals and not modified in 
      d-amphetamine-treated animals. Acute MDMA enhanced body contact and peaceful 
      following, while acute morphine and ethanol increased social sniffing. 
      CONCLUSIONS: These results provide preclinical evidence showing that while 
      different drugs of abuse affect different components of social interaction, the 
      neuronal adaptations related to drug dependence can be critically and 
      specifically influenced by group exposure.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Procopio-Souza, Roberta
AU  - Procopio-Souza R
AD  - Department of Pharmacology, Universidade Federal de Sao Paulo, R. Botucatu, 862, 
      Ed. Leal Prado, 1 degrees  andar, 04023062 Sao Paulo, SP, Brazil.
FAU - Fukushiro, Daniela F
AU  - Fukushiro DF
FAU - Trombin, Thais F
AU  - Trombin TF
FAU - Wuo-Silva, Raphael
AU  - Wuo-Silva R
FAU - Zanlorenci, Lineane H F
AU  - Zanlorenci LH
FAU - Lima, Alexandre J O
AU  - Lima AJ
FAU - Ribeiro, Luciana T C
AU  - Ribeiro LT
FAU - Correa, Jussara M R M
AU  - Correa JM
FAU - Marinho, Eduardo A V
AU  - Marinho EA
FAU - Kameda, Sonia R
AU  - Kameda SR
FAU - Andersen, Monica L
AU  - Andersen ML
FAU - Tufik, Sergio
AU  - Tufik S
FAU - Frussa-Filho, Roberto
AU  - Frussa-Filho R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110518
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Narcotics)
RN  - 3K9958V90M (Ethanol)
RN  - 76I7G6D29C (Morphine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Central Nervous System Sensitization/drug effects
MH  - Central Nervous System Stimulants/pharmacology
MH  - Dextroamphetamine/pharmacology
MH  - Ethanol/pharmacology
MH  - Hyperkinesis/*chemically induced
MH  - Injections
MH  - Male
MH  - Mice
MH  - Morphine/pharmacology
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Narcotics/pharmacology
MH  - *Social Behavior
EDAT- 2011/05/21 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/05/21 06:00
PHST- 2010/12/30 00:00 [received]
PHST- 2011/04/08 00:00 [revised]
PHST- 2011/04/19 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - S0376-8716(11)00189-X [pii]
AID - 10.1016/j.drugalcdep.2011.04.017 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2011 Nov 1;118(2-3):349-59. doi: 
      10.1016/j.drugalcdep.2011.04.017. Epub 2011 May 18.