PMID- 21596533
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20211020
IS  - 0165-1781 (Print)
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 193
IP  - 1
DP  - 2011 Jul 30
TI  - Relationship of DAT1 and adult ADHD to task-positive and task-negative working 
      memory networks.
PG  - 7-16
LID - 10.1016/j.pscychresns.2011.01.006 [doi]
AB  - Alterations in working memory, default-mode network (DMN), and dopamine 
      transporter have all been proposed as endophenotypes for 
      attention-deficit/hyperactivity disorder (ADHD). Despite evidence that these 
      systems are interrelated, their relationship to each other has never been studied 
      in the context of ADHD. In order to understand the potential mediating effects of 
      task-positive and task-negative networks between DAT1 and diagnosis, we tested 
      effects of genotype and diagnosis on regions of positive and negative BOLD signal 
      change (as measured with fMRI) in 53 adults with ADHD and 38 control subjects 
      during a working memory task. We also examined the relationship of these 
      responses to ADHD symptoms. Our results yielded four principal findings: 1) 
      association of the DAT1 9R allele with adult ADHD, 2) marginal DAT1 association 
      with task-related suppression in left medial PFC, 3) marginal genotypexdiagnosis 
      interaction in the dorsal anterior cingulate cortex, and 4) correlation of DMN 
      suppression to ADHD symptoms. These findings replicate the association of the 9R 
      allele with adult ADHD. Further, we show that DMN suppression is likely linked to 
      DAT1 and to severity of inattention in ADHD. DMN may therefore be a target of 
      DAT1 effects, and lie on the path between the gene and inattention in ADHD.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Brown, Ariel Beth
AU  - Brown AB
AD  - Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, 
      Department of Psychiatry, Massachusetts General Hospital and Harvard Medical 
      School, Boston, MA 02114, United States. ariel@nmr.mgh.harvard.edu
FAU - Biederman, Joseph
AU  - Biederman J
FAU - Valera, Eve
AU  - Valera E
FAU - Makris, Nikos
AU  - Makris N
FAU - Doyle, Alysa
AU  - Doyle A
FAU - Whitfield-Gabrieli, Susan
AU  - Whitfield-Gabrieli S
FAU - Mick, Eric
AU  - Mick E
FAU - Spencer, Thomas
AU  - Spencer T
FAU - Faraone, Stephen
AU  - Faraone S
FAU - Seidman, Larry
AU  - Seidman L
LA  - eng
GR  - R01 MH064019/MH/NIMH NIH HHS/United States
GR  - R01 MH062152/MH/NIMH NIH HHS/United States
GR  - R01 MH057934/MH/NIMH NIH HHS/United States
GR  - R01 HD036317/HD/NICHD NIH HHS/United States
GR  - MH 62152/MH/NIMH NIH HHS/United States
GR  - R01 MH062152-02/MH/NIMH NIH HHS/United States
GR  - MH 071535/MH/NIMH NIH HHS/United States
GR  - HD36317/HD/NICHD NIH HHS/United States
GR  - P41RR14075/RR/NCRR NIH HHS/United States
GR  - MH64019/MH/NIMH NIH HHS/United States
GR  - R01 HD036317-02/HD/NICHD NIH HHS/United States
GR  - K23 MH071535-01A1/MH/NIMH NIH HHS/United States
GR  - HD37694/HD/NICHD NIH HHS/United States
GR  - MH 57934/MH/NIMH NIH HHS/United States
GR  - R01 MH064019-01A2/MH/NIMH NIH HHS/United States
GR  - P41 RR014075/RR/NCRR NIH HHS/United States
GR  - R01 HD037694-01/HD/NICHD NIH HHS/United States
GR  - R01 HD037694/HD/NICHD NIH HHS/United States
GR  - K23 MH071535/MH/NIMH NIH HHS/United States
GR  - R01 MH057934-02/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110518
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (SLC6A3 protein, human)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Attention Deficit Disorder with Hyperactivity/*complications/*genetics/pathology
MH  - Brain Mapping
MH  - Dopamine Plasma Membrane Transport Proteins/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory Disorders/*etiology/genetics/pathology
MH  - Memory, Short-Term/*physiology
MH  - Middle Aged
MH  - Minisatellite Repeats/*genetics
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Prefrontal Cortex/blood supply/physiopathology
MH  - Young Adult
PMC - PMC3105199
MID - NIHMS267082
EDAT- 2011/05/21 06:00
MHDA- 2011/08/04 06:00
PMCR- 2012/07/30
CRDT- 2011/05/21 06:00
PHST- 2010/09/27 00:00 [received]
PHST- 2011/01/12 00:00 [revised]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PHST- 2012/07/30 00:00 [pmc-release]
AID - S0925-4927(11)00034-5 [pii]
AID - 10.1016/j.pscychresns.2011.01.006 [doi]
PST - ppublish
SO  - Psychiatry Res. 2011 Jul 30;193(1):7-16. doi: 10.1016/j.pscychresns.2011.01.006. 
      Epub 2011 May 18.