PMID- 21596858
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20220129
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 118
IP  - 3
DP  - 2011 Jul 21
TI  - Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 
      6p21.3.
PG  - 670-4
LID - 10.1182/blood-2011-03-339630 [doi]
AB  - Since an association between the human leukocyte antigen (HLA) region and Hodgkin 
      lymphoma (HL) was first reported in 1967, many studies have reported associations 
      between HL risk and both single nucleotide polymorphism (SNP) and classic HLA 
      allele variation in the major histocompatibility complex. However, population 
      stratification and the extent and complexity of linkage disequilibrium within the 
      major histocompatibility complex have hindered efforts to fine-map causal 
      signals. Using SNP data to impute alleles at classic HLA loci, we have conducted 
      an integrated analysis of HL risk within the HLA region in 582 early-onset HL 
      cases and 4736 controls. We confirm that the strongest signal of association 
      comes from an SNP located in the class II region, rs6903608 (odds ratio [OR] = 
      1.79, P = 6.63 x 10(-19)), which is unlikely to be driven by association to 
      HLA-DRB, DQA, or DQB alleles. In addition, we identify independent signals at 
      rs2281389 (OR = 1.73, P = 6.31 x 10(-13)), a SNP that maps closely to HLA-DPB1, 
      and the class II HLA allele DQA1*02:01 (OR = 0.56, P = 1.51 x 10(-7)). These data 
      suggest that multiple independent loci within the HLA class II region contribute 
      to the risk of developing early-onset HL.
FAU - Moutsianas, Loukas
AU  - Moutsianas L
AD  - Department of Statistics, University of Oxford, Oxford, United Kingdom.
FAU - Enciso-Mora, Victor
AU  - Enciso-Mora V
FAU - Ma, Yussanne P
AU  - Ma YP
FAU - Leslie, Stephen
AU  - Leslie S
FAU - Dilthey, Alexander
AU  - Dilthey A
FAU - Broderick, Peter
AU  - Broderick P
FAU - Sherborne, Amy
AU  - Sherborne A
FAU - Cooke, Rosie
AU  - Cooke R
FAU - Ashworth, Alan
AU  - Ashworth A
FAU - Swerdlow, Anthony J
AU  - Swerdlow AJ
FAU - McVean, Gilean
AU  - McVean G
FAU - Houlston, Richard S
AU  - Houlston RS
LA  - eng
GR  - 068545/Z/02/WT_/Wellcome Trust/United Kingdom
GR  - 076113/WT_/Wellcome Trust/United Kingdom
GR  - BREAST CANCER NOW RESEARCH CENTRE/BCN_/Breast Cancer Now/United Kingdom
GR  - 090532/Wellcome Trust/United Kingdom
GR  - G0000934/MRC_/Medical Research Council/United Kingdom
GR  - 085475/WT_/Wellcome Trust/United Kingdom
GR  - C1298/A8362/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110519
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Age of Onset
MH  - *Chromosomes, Human, Pair 6
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - HLA Antigens/*genetics
MH  - Hodgkin Disease/*epidemiology/*genetics
MH  - Humans
MH  - Models, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2011/05/21 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - S0006-4971(20)44747-0 [pii]
AID - 10.1182/blood-2011-03-339630 [doi]
PST - ppublish
SO  - Blood. 2011 Jul 21;118(3):670-4. doi: 10.1182/blood-2011-03-339630. Epub 2011 May 
      19.