PMID- 21597286
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20181201
IS  - 1421-9794 (Electronic)
IS  - 0009-3157 (Linking)
VI  - 57
IP  - 3
DP  - 2011
TI  - Suspicion of drug-drug interaction between high-dose methotrexate and proton pump 
      inhibitors: a case report - should the practice be changed?
PG  - 225-9
LID - 10.1159/000327372 [doi]
AB  - We report a case of a potential drug-drug interaction in a woman treated by a 
      first injection of high-dose methotrexate for a T-lymphoblastic lymphoma. 
      Valaciclovir, fluoxetine and pantoprazole were given concomitantly. A 
      methotrexate overdosage was shown at 36 h after infusion associated with a severe 
      renal failure. Alkaline hyperhydration, folinic acid and carboxypeptidase G2 were 
      given. Prescription analyses by pharmacists and literature research have 
      permitted us to suggest that a drug-drug interaction between methotrexate and 
      proton pump inhibitors (PPI) was responsible for this renal failure. Several 
      mechanisms of interaction were suggested and might be related to the inhibition 
      of renal methotrexate transporters by PPI, an increase in the methotrexate efflux 
      to the blood by an upregulation of multidrug resistance protein 3 by PPI or 
      genetic polymorphisms. This case shows that pharmacists can help physicians to 
      optimize patient treatment: they consensually decided on the systematic 
      discontinuation of PPI or a switch to ranitidine when patients were treated by 
      high-dose methotrexate.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Ranchon, F
AU  - Ranchon F
AD  - Clinical Oncology, Department of Pharmacy, Centre Hospitalier Lyon Sud, Hospices 
      Civils de Lyon, Pierre Benite, France.
FAU - Vantard, N
AU  - Vantard N
FAU - Gouraud, A
AU  - Gouraud A
FAU - Schwiertz, V
AU  - Schwiertz V
FAU - Franchon, E
AU  - Franchon E
FAU - Pham, B N
AU  - Pham BN
FAU - Vial, T
AU  - Vial T
FAU - You, B
AU  - You B
FAU - Bouafia, F
AU  - Bouafia F
FAU - Salles, G
AU  - Salles G
FAU - Rioufol, C
AU  - Rioufol C
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110518
PL  - Switzerland
TA  - Chemotherapy
JT  - Chemotherapy
JID - 0144731
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Antimetabolites, Antineoplastic)
RN  - 0 (Antiviral Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
RN  - D8TST4O562 (Pantoprazole)
RN  - HG18B9YRS7 (Valine)
RN  - MZ1IW7Q79D (Valacyclovir)
RN  - X4HES1O11F (Acyclovir)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*therapeutic use
MH  - Acyclovir/analogs & derivatives/therapeutic use
MH  - Antimetabolites, Antineoplastic/*adverse effects/metabolism/therapeutic use
MH  - Antiviral Agents/therapeutic use
MH  - Drug Interactions
MH  - Female
MH  - Fluoxetine/therapeutic use
MH  - Humans
MH  - Methotrexate/*adverse effects/metabolism/therapeutic use
MH  - Middle Aged
MH  - Pantoprazole
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Renal Insufficiency/etiology
MH  - Valacyclovir
MH  - Valine/analogs & derivatives/therapeutic use
EDAT- 2011/05/21 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/05/21 06:00
PHST- 2010/08/19 00:00 [received]
PHST- 2010/11/30 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 000327372 [pii]
AID - 10.1159/000327372 [doi]
PST - ppublish
SO  - Chemotherapy. 2011;57(3):225-9. doi: 10.1159/000327372. Epub 2011 May 18.