PMID- 21597829
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190606
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 2
IP  - 5
DP  - 1995 Sep
TI  - Alteration of the C-met oncogene locus in human head and neck-carcinoma.
PG  - 847-50
AB  - The c-met proto-oncogene encodes the receptor for the hepatocyte growth 
      factor/scatter factor (HGF/SF) which induces eel proliferation and motility. We 
      have analysed the genetic alteration involving the c-met locus on chromosome 7q31 
      using the pMet H polymorphic probe, in tumor and normal DNA from 87 patients with 
      head and neck squamous cell carcinomas (HNSCC). We report the observation of loss 
      of heterozygosity (LOH) at this locus in 23% of informative cases, contrasting 
      with the previously reported 40% LOH detected in breast cancer. Further, gain of 
      genetic material was also observed in 13% of the HNSCCs. The alterations of c-met 
      gene were not significantly associated with standard pronostic features including 
      tumor size and lymph node status. Involvement of the c-met locus in allelic 
      imbalance, either loss or gain of genetic material, is relatively consistent with 
      complex karyotype patterns detected in head and neck squamous cell carcinomas 
      through previous cytogenetic studies.
FAU - Muller, D
AU  - Muller D
FAU - Millon, R
AU  - Millon R
FAU - Eber, M
AU  - Eber M
FAU - Methlin, G
AU  - Methlin G
FAU - Abecassis, J
AU  - Abecassis J
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
AID - 10.3892/or.2.5.847 [doi]
PST - ppublish
SO  - Oncol Rep. 1995 Sep;2(5):847-50. doi: 10.3892/or.2.5.847.