PMID- 21598342
OWN - NLM
STAT- MEDLINE
DCOM- 20111104
LR  - 20131121
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Jul
TI  - Quantitative assessment of cardiac output and left ventricular function by 
      noninvasive phase-contrast and cine MRI: validation study with invasive 
      pressure-volume loop analysis in a swine model.
PG  - 203-10
LID - 10.1002/jmri.22587 [doi]
AB  - PURPOSE: To validate noninvasive cardiac output measurements of phase-contrast 
      magnetic resonance imaging (PC-MRI) and cine MRI using an invasive 
      pressure-volume (PV) loop technique on a swine model. MATERIALS AND METHODS: We 
      compared three methods for evaluating cardiac function at rest and under 
      pharmaceutical low-dose inotropic infusion conditions: 1) phase-contrast MRI, 2) 
      cine MRI, and 3) PV loop relationship. These measurements were made in 14 
      domestic pigs under rest conditions. Identical MRI acquisitions and PV loop 
      analysis were performed on six pigs from the same group that received an infusion 
      of dobutamine 2.5 mug/kg/min. Cardiac outputs from all measurements were analyzed 
      and compared using linear regression and Bland-Altman analysis. RESULTS: 
      Noninvasive PC-MRI and cine MRI did not show any significant differences compared 
      to an invasive PV loop technique for measurement of cardiac output under both 
      rest (PC-MRI, cine MRI, and PV loop, 3.17 +/- 0.45, 3.18 +/- 0.61, 3.45 +/- 0.41 L/min, 
      respectively) and pharmaceutical low-dose inotropic infusion conditions (PC-MRI, 
      cine MRI, and PV loop, 4.78 +/- 0.53, 4.7 +/- 0.6, 4.96 +/- 0.48 L/min, respectively). 
      Statistical analysis showed good agreement of cardiac output measurements at rest 
      (R(2) = 0.83) and under low-dose inotropic infusion conditions (R(2) = 0.74) 
      using PC-MRI and PV loop techniques. Cardiac output measurement using cine MRI 
      and PV loop techniques also showed good agreement at rest (R(2) = 0.85) and under 
      low-dose inotropic infusion conditions (R(2) = 0.76). Furthermore, cardiac 
      outputs determined with the three modalities showed good agreement over a wide 
      range of heart rates (90-180 bpm). CONCLUSION: MRI can provide a reliable, 
      noninvasive measurement of cardiac output that can be carried out without the 
      complications that are inherent with current invasive procedures.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Lin, Hung-Yu
AU  - Lin HY
AD  - Institute for Biodiagnostics, National Research Council Canada, Winnipeg, MB 
      Canada. Hung-Yu.Lin@nrc-cnrc.gc.ca
FAU - Freed, Darren
AU  - Freed D
FAU - Lee, Trevor W R
AU  - Lee TW
FAU - Arora, Rakesh C
AU  - Arora RC
FAU - Ali, Ayyaz
AU  - Ali A
FAU - Almoustadi, Waiel
AU  - Almoustadi W
FAU - Xiang, Bo
AU  - Xiang B
FAU - Wang, Fei
AU  - Wang F
FAU - Large, Stephen
AU  - Large S
FAU - King, Scott B
AU  - King SB
FAU - Tomanek, Boguslaw
AU  - Tomanek B
FAU - Tian, Ganghong
AU  - Tian G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110519
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 3S12J47372 (Dobutamine)
SB  - IM
MH  - Animals
MH  - Cardiac Output
MH  - Dobutamine/pharmacology
MH  - Electrocardiography/methods
MH  - Heart/physiology
MH  - *Heart Ventricles
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Pressure
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Swine
MH  - *Ventricular Function, Left
EDAT- 2011/05/21 06:00
MHDA- 2011/11/05 06:00
CRDT- 2011/05/21 06:00
PHST- 2010/09/15 00:00 [received]
PHST- 2011/03/04 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/11/05 06:00 [medline]
AID - 10.1002/jmri.22587 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2011 Jul;34(1):203-10. doi: 10.1002/jmri.22587. Epub 2011 
      May 19.