PMID- 21599199
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110523
IS  - 1550-2376 (Electronic)
IS  - 1539-3755 (Linking)
VI  - 83
IP  - 4 Pt 1
DP  - 2011 Apr
TI  - Mean-field study of the role of lateral cracks in microtubule dynamics.
PG  - 041905
AB  - A link between dimer-scale processes and microtubule (MT) dynamics at macroscale 
      is studied by comparing simulations obtained using computational dimer-scale 
      model with its mean-field approximation. The novelty of the mean-field model 
      (MFM) is in its explicit representation of inter-protofilament cracks, as well as 
      in the direct incorporation of the dimer-level kinetics. Due to inclusion of both 
      longitudinal and lateral dimer interactions, the MFM is two dimensional, in 
      contrast to previous theoretical models of MTs. It is the first analytical model 
      that predicts and quantifies crucial features of MT dynamics such as (i) 
      existence of a minimal soluble tubulin concentration needed for the 
      polymerization (with concentration represented as a function of model 
      parameters), (ii) existence of steady-state growth and shortening phases (given 
      with their respective velocities), and (iii) existence of an unstable pause state 
      near zero velocity. In addition, the size of the GTP cap of a growing MT is 
      estimated. Theoretical predictions are shown to be in good agreement with the 
      numerical simulations.
CI  - (c)2011 American Physical Society
FAU - Margolin, Gennady
AU  - Margolin G
AD  - Department of Applied and Computational Mathematics and Statistics, University of 
      Notre Dame, Notre Dame, Indiana 46556, USA.
FAU - Goodson, Holly V
AU  - Goodson HV
FAU - Alber, Mark S
AU  - Alber MS
LA  - eng
GR  - GM065420/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110408
PL  - United States
TA  - Phys Rev E Stat Nonlin Soft Matter Phys
JT  - Physical review. E, Statistical, nonlinear, and soft matter physics
JID - 101136452
SB  - IM
MH  - Computer Simulation
MH  - Hardness
MH  - Microtubules/*chemistry/*ultrastructure
MH  - *Models, Chemical
MH  - *Models, Molecular
MH  - Stress, Mechanical
MH  - Surface Properties
EDAT- 2011/05/24 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/24 06:00
PHST- 2010/11/06 00:00 [received]
PHST- 2011/01/22 00:00 [revised]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1103/PhysRevE.83.041905 [doi]
PST - ppublish
SO  - Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Apr;83(4 Pt 1):041905. doi: 
      10.1103/PhysRevE.83.041905. Epub 2011 Apr 8.