PMID- 21600145
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20191210
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Apr
TI  - [The efficacy and safety of mismatched hematopoietic stem cell transplantation 
      for treatment of severe aplastic anemia].
PG  - 287-90
AB  - OBJECTIVE: To study the efficacy and safety of human leukocyte antigen (HLA) 
      mismatched hematopoietic stem cell transplantation (HSCT) on severe aplastic 
      anemia (SAA). METHODS: From January 2006 to May 2010, 17 patients received 
      mismatched HSCT. HLA antigens were 3-loci-mismatched in 9 patients, 
      2-loci-mismatched in 8. All patients received recombinant human granulocyte 
      colony-stimulating factor (rhG-CSF) primed bone marrow cells plus peripheral 
      blood stem cells after modified busulfan/cyclophosphamide + antithymocyte 
      immunoglobulin (BU/CY + ATG) conditioning regimen. RESULTS: All patients achieved 
      full donor type engraftment. Grade III-IV graft versus host disease (GVHD) 
      occurred in 3 patients and extensive chronic GVHD in 1. With a median 
      following-up time of 285 (60 - 1670) d, 11 patients were alive, 9 of them had 
      normal blood counts and the other 2 were blood transfusion independent. Six 
      patients died of transplant-related complications. CONCLUSION: Mismatched HSCT is 
      a feasible and safe option for SAA patients without sibling identical donors.
FAU - Han, Wei
AU  - Han W
AD  - Institute of Hematology, People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Huang, Xiao-Jun
AU  - Huang XJ
FAU - Liu, Kai-Yan
AU  - Liu KY
FAU - Xu, Lan-Ping
AU  - Xu LP
FAU - Liu, Dai-Hong
AU  - Liu DH
FAU - Chen, Huan
AU  - Chen H
FAU - Zhang, Xiao-Hui
AU  - Zhang XH
FAU - Chen, Yu-Hong
AU  - Chen YH
FAU - Wang, Feng-Rong
AU  - Wang FR
FAU - Wang, Yu
AU  - Wang Y
LA  - chi
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Aplastic/*immunology/*surgery
MH  - Antilymphocyte Serum
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - HLA Antigens/immunology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects/*methods
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Young Adult
EDAT- 2011/05/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2011 Apr;50(4):287-90.