PMID- 21600165
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20201209
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 12
DP  - 2011 Mar 29
TI  - [Effect of furazolidone quadruple regimen plus dental plaque removal procedures 
      as rescue treatment of refractory Helicobacter pylori infection].
PG  - 836-9
AB  - OBJECTIVE: To observe the effect of furazolidone quadruple regimen plus dental 
      plaque removal procedures as rescue treatment of refractory H. pylori infection. 
      METHODS: A total of 104 patients with H. pylori positive [(13)C-urea breath test 
      (UBT) or rapid urease test positive] failing in previous treatment two or more 
      were enrolled and divided into 2 groups. One group (n = 64) were given quadruple 
      regimen [proton pump inhibitor (PPI) + bismuth + amoxicillin + furazolidone, 10 
      days] treatment and dental plaque removal treatment. And the others (n = 40) 
      received only quadruple regimen treatment. The status of H. pylori was detected 
      by (13)C-UBT at 4 weeks post-therapy and the eradication rates of two groups were 
      compared. RESULTS: The eradication rate of quadruple regimen + dental treatment 
      group was 85.9% (55/64) while that of the other group 72.5% (29/40) (P = 0.091). 
      CONCLUSION: The PPI + bismuth quadruple regimen plus dental plaque removal 
      procedures as rescue treatment may boost the eradication rate of refractory H. 
      pylori infection patients. And the furazolidone quadruple therapy can be chosen 
      for the treatment of refractory H. pylori infection. Oral H. pylori infection may 
      play a role in the failure of H. pylori infection treatment.
FAU - Gao, Wen
AU  - Gao W
AD  - Department of Gastroenterology, Peking University First Hospital, Beijing 100034, 
      China.
FAU - Hu, Fu-lian
AU  - Hu FL
FAU - Wang, Xiao-min
AU  - Wang XM
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Antacids)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Ulcer Agents)
RN  - 5J9CPU3RE0 (Furazolidone)
RN  - 804826J2HU (Amoxicillin)
RN  - U015TT5I8H (Bismuth)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Amoxicillin/therapeutic use
MH  - Antacids/therapeutic use
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Anti-Ulcer Agents/therapeutic use
MH  - Bismuth/therapeutic use
MH  - Dental Plaque/*microbiology/*therapy
MH  - Drug Therapy, Combination
MH  - Female
MH  - Furazolidone/administration & dosage/*therapeutic use
MH  - Helicobacter Infections/*drug therapy
MH  - Helicobacter pylori/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Treatment Failure
MH  - Young Adult
EDAT- 2011/05/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Mar 29;91(12):836-9.