PMID- 21600286
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20211020
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Print)
IS  - 1044-7431 (Linking)
VI  - 47
IP  - 4
DP  - 2011 Aug
TI  - Regulation of adult neurogenesis by behavior and age in the accessory olfactory 
      bulb.
PG  - 274-85
LID - 10.1016/j.mcn.2011.05.003 [doi]
AB  - The vomeronasal system (VNS) participates in the detection and processing of 
      pheromonal information related to social and sexual behaviors. Within the VNS, 
      two different populations of sensory neurons, with a distinct pattern of 
      distribution, line the epithelium of the vomeronasal organ (VNO) and give rise to 
      segregated sensory projections to the accessory olfactory bulb (AOB). Apical 
      sensory neurons in the VNO project to the anterior AOB (aAOB), while basal 
      neurons project to the posterior AOB (pAOB). In the AOB, the largest population 
      of neurons are inhibitory, the granule and periglomerular cells (GCs and PGs) and 
      remarkably, these neurons are continuously born and functionally integrated in 
      the adult brain, underscoring their role on olfactory function. Here we show that 
      behaviors mediated by the VNS differentially regulate adult neurogenesis across 
      the anterior-posterior axis of the AOB. We used immunohistochemical labeling of 
      newly born cells under different behavioral conditions in mice. Using a 
      resident-intruder aggression paradigm, we found that subordinate mice exhibited 
      increased neurogenesis in the aAOB. In addition, in sexually naive adult females 
      exposed to soiled bedding odorized by adult males, the number of newly born cells 
      was significantly increased in the pAOB; however, neurogenesis was not affected 
      in females exposed to female odors. In addition, we found that at two months of 
      age adult neurogenesis was sexually dimorphic, with male mice exhibiting higher 
      levels of newly born cells than females. Interestingly, adult neurogenesis was 
      greatly reduced with age and this decrease correlated with a decrease in 
      progenitor cells proliferation but not with an increase in cell death in the AOB. 
      These results indicate that the physiological regulation of adult neurogenesis in 
      the AOB by behaviors is both sex and age dependent and suggests an important role 
      of newly born neurons in sex dependent behaviors mediated by the VNS.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Nunez-Parra, Alexia
AU  - Nunez-Parra A
AD  - Department of Biology and Neuroscience and Cognitive Sciences Program, University 
      of Maryland, College Park, MD 20742, USA.
FAU - Pugh, Victoria
AU  - Pugh V
FAU - Araneda, Ricardo C
AU  - Araneda RC
LA  - eng
GR  - R01 DC009817/DC/NIDCD NIH HHS/United States
GR  - R01 DC009817-01A1/DC/NIDCD NIH HHS/United States
GR  - DC RO1-DC-009817/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110510
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Pheromones)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurogenesis/*physiology
MH  - Odorants
MH  - Olfactory Bulb/cytology/*physiology
MH  - Pheromones/metabolism
MH  - Sensory Receptor Cells/cytology/physiology
MH  - Sex Characteristics
MH  - Smell
PMC - PMC3137699
MID - NIHMS295973
EDAT- 2011/05/24 06:00
MHDA- 2011/12/13 00:00
PMCR- 2012/08/01
CRDT- 2011/05/24 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2011/04/16 00:00 [revised]
PHST- 2011/05/03 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - S1044-7431(11)00109-6 [pii]
AID - 10.1016/j.mcn.2011.05.003 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2011 Aug;47(4):274-85. doi: 10.1016/j.mcn.2011.05.003. Epub 
      2011 May 10.