PMID- 21601844
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20110725
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 111
IP  - 6
DP  - 2011 Aug
TI  - The effect of prenatal perfluorinated chemicals exposures on pediatric atopy.
PG  - 785-91
LID - 10.1016/j.envres.2011.04.006 [doi]
AB  - BACKGROUND: The role of perfluorinated compounds (PFCs) in the immune system and 
      allergic diseases is not well-known. This study examined the effects of pre-natal 
      exposure to PFCs on immunoglobulin E (IgE) levels and atopic dermatitis (AD). 
      METHODS: In Taiwan Birth Panel cohort study, newborns with cord blood and 
      peri-natal factors (i.e. birth body weight, weeks of gestation, and type of 
      delivery) gathered at birth were evaluated. At the age of 2 years, information on 
      the development of AD, environmental exposures, and serum total IgE were 
      collected. The AD and non-AD children were compared for the concentration of cord 
      blood serum PFCs measured by Ultra-performance liquid 
      chromatography/triple-quadrupole mass (UPLC-MS/MS). Correlations among cord blood 
      IgE, serum total IgE at 2 years of age, and cord blood PFC levels were made. 
      RESULTS: Of 244 children who completed the follow-up and specimen collections, 43 
      (17.6%) developed AD. Concentrations of cord blood serum perfluorooctanoic acid 
      (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and 
      perfluorohexane sulfonic acid (PFHxS) were median (range) 1.71 (0.75-17.40), 5.50 
      (0.11-48.36), 2.30 (0.38-63.87), and 0.035 (0.035-0.420)ng/mL, respectively. PFOA 
      and PFOS levels positively correlated with cord blood IgE levels (per ln-unit: 
      beta=0.134 KU/l, p=0.047 for PFOA; beta=0.161 KU/l, p=0.017 for PFOS). Analyses 
      stratified by gender revealed that PFOA and PFOS levels positively correlated 
      with cord blood IgE levels only in boys (per ln-unit: beta=0.206 KU/l, p=0.025 for 
      PFOA; beta=0.175 KU/l, p=0.053 for PFOS). When dividing cord blood serum PFCs into 
      quartiles in the fully adjusted models, AD had no significant association with 
      PFOS. CONCLUSIONS: Pre-natal PFOA and PFOS exposures positively correlated with 
      cord blood IgE levels.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Wang, I-Jen
AU  - Wang IJ
AD  - Department of Pediatrics, Taipei Hospital, Department of Health, Taipei, Taiwan.
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
FAU - Chen, Chia-Yang
AU  - Chen CY
FAU - Fletcher, Tony
AU  - Fletcher T
FAU - Lien, Guang-Wen
AU  - Lien GW
FAU - Chiang, Hung-Lung
AU  - Chiang HL
FAU - Chiang, Chow-Feng
AU  - Chiang CF
FAU - Wu, Trong-Neng
AU  - Wu TN
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110523
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Fluorocarbons)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dermatitis, Atopic/*epidemiology/etiology/immunology
MH  - Female
MH  - Fetal Blood/chemistry/immunology
MH  - Fluorocarbons/blood/immunology/*toxicity
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Infant, Newborn
MH  - Male
MH  - *Maternal Exposure
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/epidemiology/immunology
MH  - Sex Factors
MH  - Taiwan
EDAT- 2011/05/24 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/24 06:00
PHST- 2010/10/14 00:00 [received]
PHST- 2011/02/26 00:00 [revised]
PHST- 2011/04/19 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0013-9351(11)00115-0 [pii]
AID - 10.1016/j.envres.2011.04.006 [doi]
PST - ppublish
SO  - Environ Res. 2011 Aug;111(6):785-91. doi: 10.1016/j.envres.2011.04.006. Epub 2011 
      May 23.