PMID- 21602034
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20200109
IS  - 1778-3585 (Electronic)
IS  - 0924-9338 (Linking)
VI  - 27
IP  - 6
DP  - 2012 Aug
TI  - Negative symptoms and psychosocial functioning in schizophrenia: neglected but 
      important targets for treatment.
PG  - 432-6
LID - 10.1016/j.eurpsy.2011.02.015 [doi]
AB  - BACKGROUND: Many patients with schizophrenia suffer from poor social functioning, 
      with high levels of unemployment being one particular consequence. Negative 
      symptoms tend to persist during periods of clinical stability and may have a 
      detrimental effect on function. This paper aims to investigate the relationship 
      between negative symptoms and ability to function. METHODS: The EGOFORS study 
      measured negative symptoms in 295 schizophrenia patients in 11 European sites 
      using the PANSS Negative Subscale and assessment scales for psychosocial 
      function: Global Assessment of Functioning (GAF), Personal and Social Performance 
      (PSP), Quality of Life Scale (QLS), Functional Remission of General Schizophrenia 
      (FROGS), Psychosocial Remission in Schizophrenia (PSRS) and Subjective Wellbeing 
      under Neuroleptics (SWN). The relationships between the PANSS Negative Subscale 
      and the functional scales were investigated, adjusting for differences between 
      study sites. Being in work, duration of illness, age of onset and number of years 
      of education were also investigated for a relationship with function. RESULTS: 
      There were strong, statistically significant correlations between PANSS Negative 
      Subscale and all of the function scales (95% confidence intervals for the 
      correlation coefficients: PSRS 0.77-0.91; FROGS 0.74-0.89; QLS 0.74-0.92; GAF 
      0.64-0.78; PSP 0.63-0.80) except the SWN. All of the functional scales except SWN 
      were at least moderately related to one another. All of the items in each of the 
      PANSS Negative Subscale and the function scales contributed to the relationships 
      between them. Better functioning correlated strongly with participants being in 
      work. CONCLUSION: This study shows a strong and significant relationship between 
      negative symptoms and psychosocial functioning. Given the impact of negative 
      symptoms on psychosocial function, much more emphasis should be placed on 
      developing effective treatments for negative symptoms, given that most patients 
      with schizophrenia now live in community settings and require to function 
      adequately to support their quality of life.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Hunter, R
AU  - Hunter R
AD  - Psychiatric Research Institute for Neuroscience in Glasgow, West Medical 
      Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom. 
      robert.hunter@glasgow.ac.uk
FAU - Barry, S
AU  - Barry S
LA  - eng
PT  - Journal Article
DEP - 20110523
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life
MH  - Schizophrenia/*drug therapy
MH  - Schizophrenic Psychology
MH  - *Social Adjustment
MH  - Treatment Outcome
EDAT- 2011/05/24 06:00
MHDA- 2012/12/14 06:00
CRDT- 2011/05/24 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2011/02/03 00:00 [revised]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - S0924-9338(11)00045-9 [pii]
AID - 10.1016/j.eurpsy.2011.02.015 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2012 Aug;27(6):432-6. doi: 10.1016/j.eurpsy.2011.02.015. Epub 
      2011 May 23.