PMID- 2160241
OWN - NLM
STAT- MEDLINE
DCOM- 19900620
LR  - 20141120
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 40
IP  - 1
DP  - 1990 Jan
TI  - Effect of the new anti-allergic compound ethyl 
      2-(4'-carboxybenzamido)-4-propionamidobenzoate sodium salt on human neutrophil 
      superoxide production.
PG  - 91-4
AB  - The effect of the new orally active antiallergic compound ethyl 
      2-(4'-carboxybenzamido)-4-propionamidobenzoate sodium salt (AM-682) and its main 
      metabolite (met-A) were evaluated on respiratory burst in isolated human 
      polymorphonuclear neutrophils (PMN). Both compounds exhibited inhibitory effect 
      with concentration dependency on the n-formyl-methionyl-leucyl-phenylalanine 
      (FMLP)-induced superoxide (O-2) production by human PMN. The inhibitory activity 
      of met-A (IC50 1.1 mumol/l) was higher than that of AM-682 (IC50 85 mumol/l). By 
      contrast, these compounds affected neither PMN O-2 production induced by phorbol 
      12-myristate 13-acetate (PMA) nor extracellular O-2 generation by the reaction of 
      xanthine oxidase with hypoxanthine. These results indicate that the effects of 
      these compounds act specifically on the generation of O-2 and is not simply a 
      scavenger of O-2. This anti-inflammatory effect may also be beneficial in the 
      treatment of asthma.
FAU - Kaneko, M
AU  - Kaneko M
AD  - 2nd Department of Internal Medicine, Nagoya University School of Medicine, Japan.
FAU - Suzuki, K
AU  - Suzuki K
FAU - Furui, H
AU  - Furui H
FAU - Takagi, K
AU  - Takagi K
FAU - Satake, T
AU  - Satake T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Aminobenzoates)
RN  - 0 (Benzamides)
RN  - 0 (Cytochrome c Group)
RN  - 0 (para-Aminobenzoates)
RN  - 11062-77-4 (Superoxides)
RN  - 124391-91-9 (ethyl 2-(4'-carboxybenzamido)-4-propionamidobenzoate)
RN  - 73626-07-0 (ethyl 2-(4'-carboxybenzamido)-4-aminobenzoate)
SB  - IM
MH  - Adult
MH  - Aminobenzoates/*pharmacology
MH  - Benzamides/*pharmacology
MH  - Cytochrome c Group/metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Male
MH  - Neutrophils/drug effects/*metabolism
MH  - Oxidation-Reduction
MH  - Oxygen Consumption/drug effects
MH  - Superoxides/*metabolism
MH  - para-Aminobenzoates
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1990 Jan;40(1):91-4.