PMID- 21602719
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20131121
IS  - 1536-3678 (Electronic)
IS  - 1077-4114 (Linking)
VI  - 33
IP  - 5
DP  - 2011 Jul
TI  - Plasma homocysteine levels, methylene tetrahydrofolate reductase polymorphisms, 
      and the risk of thromboembolism in children.
PG  - 330-3
LID - 10.1097/MPH.0b013e318219324f [doi]
AB  - INTRODUCTION: Hyperhomocystenemia (HHcy) is a risk factor for thrombosis in 
      adults. Polymorphisms in methylene tetrahydrofolate reductase (MTHFR) enzyme may 
      cause HHcy. Data on their role in pediatric thromboembolism (TE) are sparse. 
      MATERIALS AND METHODS: Charts of patients from 1989 to 2007, with documented TE, 
      were reviewed. Homocysteine (Hcy) levels were defined both as per the adult 
      normal range and the age-specific normal ranges from literature. RESULTS: A total 
      of 141 patients (67 females, 74 males) were identified. With age-specific normal 
      ranges for Hcy, 15 patients were found to have HHcy: 6 had CT, 9 patients had CC, 
      and none had TT MTHFR genotype. When adult normal range was used, HHcy (>12 
      mumol/L) was seen in 7 patients: 4 had CT and 3 had the CC genotype. Again, none 
      had TT genotype. In addition, the mean Hcy levels were unaffected by sex and 
      ethnicities, but universal folic acid supplementation (post 1996) lowered the 
      mean. CONCLUSIONS: (1) Age-specific ranges for Hcy should be used in pediatrics 
      for accurate diagnosis of HHcy. (2) MTHFR C677T polymorphism is not a risk factor 
      in pediatric TE. (3) Folic acid supplementation could play a role in lowering the 
      prevalence of HHcy.
FAU - Nahar, Akash
AU  - Nahar A
AD  - Division of Hematology Oncology, Carman and Ann Adams Department of Pediatrics, 
      Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA.
FAU - Sabo, Cynthia
AU  - Sabo C
FAU - Chitlur, Meera
AU  - Chitlur M
FAU - Ravindranath, Yaddanapudi
AU  - Ravindranath Y
FAU - Lusher, Jeanne
AU  - Lusher J
FAU - Rajpurkar, Madhvi
AU  - Rajpurkar M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Folic Acid/therapeutic use
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genotype
MH  - Homocysteine/*blood
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics/metabolism
MH  - *Polymorphism, Genetic
MH  - Prevalence
MH  - Reference Values
MH  - Risk Factors
MH  - Thromboembolism/blood/*epidemiology/*genetics
MH  - Vitamin B Complex/therapeutic use
MH  - Young Adult
EDAT- 2011/05/24 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1097/MPH.0b013e318219324f [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2011 Jul;33(5):330-3. doi: 10.1097/MPH.0b013e318219324f.