PMID- 21602842
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 1745-7254 (Electronic)
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 32
IP  - 6
DP  - 2011 Jun
TI  - Pregnant phenotype in aquaporin 8-deficient mice.
PG  - 840-4
LID - 10.1038/aps.2011.45 [doi]
AB  - AIM: Aquaporin 8 (AQP8) is expressed within the female reproductive system but 
      its physiological function reminds to be elucidated. This study investigates the 
      role of AQP8 during pregnancy using AQP8-knockout (AQP8-KO) mice. METHODS: 
      Homozygous AQP8-KO mice were mated, and the conception rate was recorded. AQP8-KO 
      pregnant mice or their offspring were divided into 5 subgroups according to fetal 
      gestational day (7, 13, 16, 18 GD) and newborn. Wild type C57 pregnant mice 
      served as the control group. The number of pregnant mice, total embryos and 
      atrophic embryos, as well as fetal weight, placental weight and placental area 
      were recorded for each subgroup. The amount of amniotic fluid in each sac at 13, 
      16, and 18 GD was calculated. Statistical significance was determined by analysis 
      of variance of factorial design and chi-square tests. RESULTS: Conception rates 
      did not differ significantly between AQP8-KO and wild type mice. AQP8-KO pregnant 
      mice had a significantly higher number of embryos compared to wild type controls. 
      Fetal/neonatal weight was also significantly greater in the AQP8-KO group 
      compared to age-matched wild type controls. The amount of amniotic fluid was 
      greater in AQP8-KO pregnant mice than wild type controls, although the FM/AFA 
      (fetal weight/amniotic fluid amount) did not differ. While AQP8-KO placental 
      weight was significantly larger than wild type controls, there was no evidence of 
      placental pathology in either group. CONCLUSION: The results suggest that AQP8 
      deficiency plays an important role in pregnancy outcome.
FAU - Sha, Xiao-yan
AU  - Sha XY
AD  - Department of Obstetrics, Guangzhou Women and Children's Medical Centre, 
      Guangzhou Medical College, Guangzhou 510623, China.
FAU - Xiong, Zheng-fang
AU  - Xiong ZF
FAU - Liu, Hui-shu
AU  - Liu HS
FAU - Zheng, Zheng
AU  - Zheng Z
FAU - Ma, Tong-hui
AU  - Ma TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110523
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
RN  - 0 (Aquaporins)
RN  - 0 (aquaporin 8)
SB  - IM
MH  - Amniotic Fluid/metabolism/physiology
MH  - Animals
MH  - Aquaporins/*deficiency/genetics/*physiology
MH  - Female
MH  - Fetal Weight/physiology
MH  - Gestational Age
MH  - Litter Size/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Organ Size/physiology
MH  - Phenotype
MH  - Placenta/metabolism/physiology
MH  - Pregnancy
MH  - *Pregnancy Outcome
PMC - PMC4009960
EDAT- 2011/05/24 06:00
MHDA- 2011/10/01 06:00
PMCR- 2011/06/01
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - aps201145 [pii]
AID - 10.1038/aps.2011.45 [doi]
PST - ppublish
SO  - Acta Pharmacol Sin. 2011 Jun;32(6):840-4. doi: 10.1038/aps.2011.45. Epub 2011 May 
      23.