PMID- 21603246
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1179-5549 (Electronic)
IS  - 1179-5549 (Linking)
VI  - 5
DP  - 2011
TI  - The role of T lymphocytes in cancer patients undergoing immunotherapy with 
      autologous dendritic cells.
PG  - 107-15
LID - 10.4137/CMO.S6927 [doi]
AB  - INTRODUCTION: Cancer stems from mutations in specific genes that induce 
      uncontrolled cell proliferation. Dendritic cells (DCs) are important immunologic 
      cells and play a crucial role in the induction of an antitumour response. 
      PATIENTS AND METHODS: We examined the immune response mediated by T lymphocytes, 
      helper T cells, cytotoxic T cells, and regulatory T cells, as well as the 
      cytokines [interleukin (IL)-2, IL-12, interferon (IFN)-gamma, tumour necrosis factor 
      (TNF)-alpha and IL-10], produced by these cell populations, in cancer patients (N = 
      7) undergoing immunotheraphy with autologous DCs. RESULTS: We observed an initial 
      increase in T helper cells (CD4+) expressing IL-2, IFN-gamma, IL-12, TNF-alpha, and IL-10 
      after initiation of treatment, with statistically significant for the cytokines 
      IL-2, TNF-alpha and IL-10. A similar significant effect was observed for 
      IL-2-expressing cytotoxic T cells (CD8+). The percentage of total T cells (CD3+) 
      remained elevated throughout immunotherapy. Regulatory T cells (CD25+/FOXP3+) 
      only showed high percentage of their maximum value when analyzed the pretreatment 
      levels, with statistically significant. CONCLUSION: Immunotherapy with DCs 
      stimulated the immune response, as evidenced by an increase in percent 
      fluorescence of most cell populations investigated during the specified treatment 
      period.
FAU - Rodrigues, Claudia M
AU  - Rodrigues CM
AD  - Research Institute for Oncology-IPON, Federal University of the Triangulo 
      Mineiro-UFTM, Uberaba, Minas Gerais, Brazil.
FAU - Matias, Bruna F
AU  - Matias BF
FAU - Murta, Eddie F C
AU  - Murta EF
FAU - Michelin, Marcia A
AU  - Michelin MA
LA  - eng
PT  - Journal Article
DEP - 20110425
PL  - United States
TA  - Clin Med Insights Oncol
JT  - Clinical Medicine Insights. Oncology
JID - 101525771
PMC - PMC3095027
OTO - NOTNLM
OT  - T cells
OT  - cancer
OT  - cytokines
OT  - dendritic cells
OT  - immunotherapy
EDAT- 2011/05/24 06:00
MHDA- 2011/05/24 06:01
PMCR- 2011/04/25
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/05/24 06:01 [medline]
PHST- 2011/04/25 00:00 [pmc-release]
AID - cmo-2011-107 [pii]
AID - 10.4137/CMO.S6927 [doi]
PST - ppublish
SO  - Clin Med Insights Oncol. 2011;5:107-15. doi: 10.4137/CMO.S6927. Epub 2011 Apr 25.