PMID- 21604464
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20221207
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Mar
TI  - [The association between genetic polymorphisms of GSTM1, GSTT1, GSTP1 and 
      susceptibility to laryngeal carcinoma from the Han people in Guangdong zone].
PG  - 204-10
AB  - OBJECTIVE: To analyze the association between genetic polymorphisms of 
      xenobiotic- metabolizing enzymes GSTM1, GSTT1, GSTP1 and susceptibility to 
      laryngeal carcinoma from the Han people in Guangdong zone. METHOD: A case-control 
      study was conducted involving 233 LSCC (laryngeal squamous cell carcinoma) 
      patients and 102 healthy controls to investigate the association between 
      polymorphisms of GSTM1, GSTT1, GSTP1 (Ile/Val) and LSCC from the Han people in 
      Guangdong zone. All blood samples of the Han people from the Guangdong zone was 
      analyzed with methods of PCR, ASA and the DNA sequencing technique with 
      sequenator. We explored the association between polymorphisms and the clinical 
      pathologic characteristics of LSCC. The data was processed with SPSS13.0. Odds 
      Ratios (ORs) with 95% CI for relevancy intensity were calculated using binary 
      logistic regression analysis. RESULT: The frequency of GSTM1(-) and GSTT1(-) 
      genotype was higher in LSCC than that in healthy controls (OR = 2.61, 3.05, P < 
      0.01). There was synergic effect between GSTT1 (-) genotype and heavily smoking 
      during carcinogenesis of LSCC (OR = 3.51, 95% CI 2.05-5.01; OR = 2.99, 95% CI 
      2.00-4.49). The frequency of GSTM1(-) and GSTT1(-) genotype was higher in LSCC 
      whose family had carcinoma history. The frequency of advanced LSCC was higher in 
      patients who were with GSTM1(-) and GSTT1 (-) genotype (P < 0.05). There was no 
      difference of the frequency of GSTP1(I le/Val) genotype between and in healthy 
      controls (P > 0.05). CONCLUSION: There may be an association between the 
      susceptibility to carcinoma and GSTT1(-), GSTM1(-) genotype. The GSTT1(-) 
      polymorphism c gene cooperating with heavily smoking boost up the susceptibility 
      of individual to laryngeal carcinoma. The GSTM1(-) polymorphism c may not 
      cooperating with smoking during carcinogenesis of LSCC in the Han people in 
      Guangdong zone. The morphisms of GSTT1 and GSTM1 gene may affect the 
      carcino-genesis of LSCC in the Han people in Guangdong zone. There may be no 
      association between the susceptibility to laryngeal carcinoma and the 
      GSTP1(Ile/Val) type.
FAU - Tian, Shenzhi
AU  - Tian S
AD  - Department of Otolaryngology, Second Hospital Affiliated to Guangzhou Medical 
      College, Guangzhou 510260, China. tisinger@163.com
FAU - Zhang, Jianguo
AU  - Zhang J
FAU - Xiao, Qi
AU  - Xiao Q
FAU - Zhai, Jinming
AU  - Zhai J
FAU - Yan, Xiaoling
AU  - Yan X
FAU - Huang, Minqi
AU  - Huang M
FAU - Chen, Fujin
AU  - Chen F
FAU - Li, Qiuli
AU  - Li Q
FAU - Guan, Zhong
AU  - Guan Z
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (GSTP1 protein, human)
RN  - EC 2.5.1.18 (Glutathione S-Transferase pi)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Glutathione S-Transferase pi/*genetics
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Laryngeal Neoplasms/epidemiology/ethnology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
EDAT- 2011/05/25 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Mar;25(5):204-10.