PMID- 21604575
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20110523
IS  - 1003-9279 (Print)
IS  - 1003-9279 (Linking)
VI  - 24
IP  - 6
DP  - 2010 Dec
TI  - [Incidence and relationship of human cytomegalovirus infection and human 
      herpesvirus 6 infection in pediatric patients after hemopoietic stem cell 
      transplantation].
PG  - 455-7
AB  - OBJECTIVE: To study the incidence of human cytomegalovirus (CMV) and human 
      herpesvirus 6 (HHV-6) infection in pediatric patients with hemopoietic stem cell 
      transplantation (HSCT), and to explore the relationship between CMV and HHV-6 
      infection in pediatric patients with HSCT. METHODS: Pediatric patients with HSCT 
      in hemotology center of Beijing Children's Hospital were enrolled into this study 
      from June 2007 to October 2009. Peripheral blood were collected every week after 
      HSCT, and Fluorescent quantitation PCR and conventional PCR were used to detect 
      CMV DNA load in serum and HHV-6 DNA in peripheral blood respectively. Genetic 
      typing was conducted on HHV-6. RESULTS: Fifty two pediatric patients with HSCT 
      were enrolled into this study, and six hundreds and thirty six specimens were 
      collected totally. CMV DNA was detected in fifty two specimens from twenty cases. 
      The median time was 56 days after HSCT. The incidence of CMV infection was 38.5% 
      (20/52) in all HSCT patients and 47.6% (20/42) in allogene HSCT patients. The 
      incidence of late CMV infection was 22.2% (6/27) in allogene HSCT. Three patients 
      died of CMV infection,and two died of CMV interstitial pneumonia. HHV-6 DNA was 
      detected in thirty three specimens from fourteen cases. The median time was 23 
      days after HSCT. The incidence of HHV-6 infection was 26.9% (14/52)in all HSCT 
      patients and 31% (13/42) in allogene HSCT patients. The genotype of HHV6 was all 
      type B. HHV-6 DNA was positive in six of twenty cases with CMV infection. The 
      incidence of co-infection was 30% (6/20). CONCLUSIONS: There was a substantial 
      incidence of CMV and HHV6 infection after HSCT. The relationship between earlier 
      HHV6 infection and later CMV infection in pediatric patients with HSCT need 
      further study.
FAU - Lv, Dian-Yi
AU  - Lv DY
AD  - Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 
      100045, China.
FAU - Qin, Mao-Quan
AU  - Qin MQ
FAU - Wang, Yan
AU  - Wang Y
FAU - Gao, Li-Wei
AU  - Gao LW
FAU - Xie, Zheng-De
AU  - Xie ZD
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
JT  - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang 
      bingduxue zazhi = Chinese journal of experimental and clinical virology
JID - 9602873
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus/*genetics
MH  - Cytomegalovirus Infections/*etiology/immunology
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesviridae Infections/*etiology/immunology
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Infant
MH  - Male
MH  - Molecular Typing/methods
EDAT- 2011/05/25 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
PST - ppublish
SO  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Dec;24(6):455-7.