PMID- 2160481
OWN - NLM
STAT- MEDLINE
DCOM- 19900626
LR  - 20131121
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 294
IP  - 4
DP  - 1990 Apr 22
TI  - Serotoninergic innervation of the locust mandibular closer muscle modulates 
      contractions through the elevation of cyclic adenosine monophosphate.
PG  - 623-32
AB  - The mandibular closer muscles of the locust receive innervation that is 
      immunoreactive for the putative transmitter 5-hydroxytryptamine (5-HT). 
      Cobalt-labelling suggests that the origin of this innervation is a group of cells 
      located anteriorly in the suboesophageal ganglion. Bath application of 5-HT while 
      the muscles are active produces marked changes in the contractions, increasing 
      their amplitude, rate of contraction, and rate of relaxation. Incubation of 
      isolated muscles with 5-HT shows that this amine elevates the levels of the 
      cyclic nucleotide cyclic adenosine monophosphate (cAMP). In addition compounds 
      that artificially elevate the levels of cAMP in the 
      muscle--3-isobutyl-1-methylxanthine (IBMX), forskolin, and the cAMP analogue 
      8-(4-chlorophenylthio) cAMP--mimic the actions of 5-HT, whereas a potent 
      inhibitor of insect adenylate cyclase, adenosine, considerably delays the onset 
      of the effects produced by 5-HT. The effects observed with 5-HT in the mandibular 
      muscle are similar to those of octopamine in the locust extensor tibiae muscle, 
      and it is possible that this is an analogous modulatory system.
FAU - Baines, R A
AU  - Baines RA
AD  - Department of Biology, University of Waterloo, Ontario, Canada.
FAU - Tyrer, N M
AU  - Tyrer NM
FAU - Downer, R G
AU  - Downer RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 333DO1RDJY (Serotonin)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Cyclic AMP/*physiology
MH  - Female
MH  - Grasshoppers/*physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Mandible/*physiology
MH  - Motor Neurons/cytology/*metabolism/physiology
MH  - *Muscle Contraction
MH  - Muscles/cytology/*innervation/physiology
MH  - Serotonin/*physiology
EDAT- 1990/04/22 00:00
MHDA- 1990/04/22 00:01
CRDT- 1990/04/22 00:00
PHST- 1990/04/22 00:00 [pubmed]
PHST- 1990/04/22 00:01 [medline]
PHST- 1990/04/22 00:00 [entrez]
AID - 10.1002/cne.902940409 [doi]
PST - ppublish
SO  - J Comp Neurol. 1990 Apr 22;294(4):623-32. doi: 10.1002/cne.902940409.