PMID- 21605597
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20141120
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 223
IP  - 2
DP  - 2011 Oct 1
TI  - Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor 
      gating deficit?
PG  - 336-41
LID - 10.1016/j.bbr.2011.04.051 [doi]
AB  - Evidence suggests that the heterozygous transmembrane domain mutant mouse model 
      for the schizophrenia candidate gene neuregulin 1 (Nrg1 HET) exhibits a deficit 
      in prepulse inhibition (PPI). However, not all mouse models for Nrg1 exhibit PPI 
      deficits. Thus, our study intended to clarify the severity of the initially 
      described PPI deficit in Nrg1 HET mice. For this, Nrg1 mutant mice and wild 
      type-like littermates of one breeding colony were tested for PPI in four 
      different phenotyping facilities in Australia employing a variety of different 
      PPI protocols with fixed and variable interstimulus intervals (ISIs). Testing 
      mutant and wild type-like mice in three Australian phenotyping facilities using 
      PPI protocols with variable ISIs revealed no effect of mutant transmembrane 
      domain Nrg1 on sensorimotor gating. Changes to the startle response and startle 
      response habituation were site/protocol-specific. The employment of two different 
      PPI protocols at the same phenotyping facility revealed a protocol-dependent and 
      site-specific facilitation of PPI in Nrg1 mutant mice compared to wild type-like 
      mice. In conclusion, the often-noted PPI phenotype of the transmembrane domain 
      Nrg1 mutant mouse model is highly PPI protocol-specific and appears sensitive to 
      the particular conditions of the test laboratory. Our study describes wild 
      type-like PPI under most test conditions and across three different laboratories. 
      The research suggests that analysing one of the alleged hallmarks of animal 
      models for schizophrenia must be done carefully: to obtain reliable PPI data it 
      seems necessary to use more than one particular PPI protocol.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Karl, T
AU  - Karl T
AD  - Schizophrenia Research Institute, Darlinghurst, NSW, Australia. 
      t.karl@neura.edu.au
FAU - Burne, T H J
AU  - Burne TH
FAU - Van den Buuse, M
AU  - Van den Buuse M
FAU - Chesworth, R
AU  - Chesworth R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110513
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Neuregulin-1)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Disease Models, Animal
MH  - Habituation, Psychophysiologic/genetics/physiology
MH  - Male
MH  - Membrane Potentials/physiology
MH  - Mice
MH  - Mutation/*physiology
MH  - Neuregulin-1/*genetics/*physiology
MH  - Reflex, Startle/physiology
MH  - Schizophrenia
MH  - Sensory Gating/*genetics/*physiology
EDAT- 2011/05/25 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/04/27 00:00 [revised]
PHST- 2011/04/30 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0166-4328(11)00386-X [pii]
AID - 10.1016/j.bbr.2011.04.051 [doi]
PST - ppublish
SO  - Behav Brain Res. 2011 Oct 1;223(2):336-41. doi: 10.1016/j.bbr.2011.04.051. Epub 
      2011 May 13.