PMID- 2160650 OWN - NLM STAT- MEDLINE DCOM- 19900625 LR - 20190818 IS - 0196-9781 (Print) IS - 0196-9781 (Linking) VI - 11 IP - 1 DP - 1990 Jan-Feb TI - ACTH/MSH(4-10) peptide increases postnatal metabolic activity of EDL muscle following early prenatal administration. PG - 177-9 AB - ACTH/MSH(4-10) (10 micrograms/kg/b.i.d.; IP), administered to pregnant Sprague-Dawley rats during gestational days (GD) 3 to 12, significantly increased the metabolic activity of extensor digitorum longus (EDL) muscle at postnatal day 14. ACTH/MSH peptide, administered from day of birth to postnatal day 13, had no effect on EDL muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator. By postnatal day 30, no differences were seen between the early prenatally treated group and saline controls. These results confirm our previous electrophysiological studies that showed that early prenatal ACTH/MSH(4-10) administration accelerates EDL muscle maturation. FAU - Rose, K J AU - Rose KJ AD - Department of Biology, New York University, New York 10003. FAU - Strand, F L AU - Strand FL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Peptides JT - Peptides JID - 8008690 RN - 0 (Peptide Fragments) RN - 9002-60-2 (Adrenocorticotropic Hormone) RN - 9002-79-3 (Melanocyte-Stimulating Hormones) RN - J48AU3I790 (ACTH (4-10)) SB - IM MH - Adrenocorticotropic Hormone/*pharmacology MH - Animals MH - Female MH - Melanocyte-Stimulating Hormones/*pharmacology MH - Muscle Development MH - Muscles/*drug effects/metabolism MH - Peptide Fragments/*pharmacology MH - Pregnancy MH - *Prenatal Exposure Delayed Effects MH - Rats MH - Rats, Inbred Strains EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] AID - 0196-9781(90)90128-R [pii] AID - 10.1016/0196-9781(90)90128-r [doi] PST - ppublish SO - Peptides. 1990 Jan-Feb;11(1):177-9. doi: 10.1016/0196-9781(90)90128-r.