PMID- 21606539
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20211020
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 203
IP  - 12
DP  - 2011 Jun 15
TI  - The relation of HLA genotype to hepatitis C viral load and markers of liver 
      fibrosis in HIV-infected and HIV-uninfected women.
PG  - 1807-14
LID - 10.1093/infdis/jir192 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) class I and II genotype is associated 
      with clearance of hepatitis C virus (HCV) infection, but little is known 
      regarding its relation with HCV viral load or risk of liver disease in patients 
      with persistent HCV infection. METHODS: High-resolution HLA class I and II 
      genotyping was conducted in a prospective cohort of 519 human immunodeficiency 
      virus (HIV)-seropositive and 100 HIV-seronegative women with persistent HCV 
      infection. The end points were baseline HCV viral load and 2 noninvasive indexes 
      of liver disease, fibrosis-4 (FIB-4), and the aspartate aminotransferase to 
      platelet ratio index (APRI), measured at baseline and prospectively. RESULTS: 
      DQB1*0301 was associated with low baseline HCV load (beta = -.4; 95% confidence 
      interval [CI], -.6 to -.3; P < .00001), as well as with low odds of FIB-4-defined 
      (odds ratio [OR], .5; 95% CI, .2-.9; P = .02) and APRI-defined liver fibrosis 
      (OR, .5; 95% CI, .3-1.0; P = .06) at baseline and/or during follow-up. Most 
      additional associations with HCV viral load also involved HLA class II alleles. 
      Additional associations with FIB-4 and APRI primarily involved class I alleles, 
      for example, the relation of B*1503 with APRI-defined fibrosis had an OR of 2.0 
      (95% CI, 1.0-3.7; P = .04). CONCLUSIONS: HLA genotype may influence HCV viral 
      load and risk of liver disease, including DQB1*0301, which was associated with 
      HCV clearance in prior studies.
FAU - Kuniholm, Mark H
AU  - Kuniholm MH
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA. mark.kuniholm@einstein.yu.edu
FAU - Gao, Xiaojiang
AU  - Gao X
FAU - Xue, Xiaonan
AU  - Xue X
FAU - Kovacs, Andrea
AU  - Kovacs A
FAU - Marti, Darlene
AU  - Marti D
FAU - Thio, Chloe L
AU  - Thio CL
FAU - Peters, Marion G
AU  - Peters MG
FAU - Greenblatt, Ruth M
AU  - Greenblatt RM
FAU - Goedert, James J
AU  - Goedert JJ
FAU - Cohen, Mardge H
AU  - Cohen MH
FAU - Minkoff, Howard
AU  - Minkoff H
FAU - Gange, Stephen J
AU  - Gange SJ
FAU - Anastos, Kathryn
AU  - Anastos K
FAU - Fazzari, Melissa
AU  - Fazzari M
FAU - Young, Mary A
AU  - Young MA
FAU - Strickler, Howard D
AU  - Strickler HD
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - R01 AI052065/AI/NIAID NIH HHS/United States
GR  - R56 AI052065/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Alleles
MH  - Aspartate Aminotransferases/blood
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - HIV Infections/*complications
MH  - HLA Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - Hepacivirus/*pathogenicity
MH  - Hepatitis C, Chronic/complications/*virology
MH  - Humans
MH  - Liver Cirrhosis/blood/*genetics/virology
MH  - Logistic Models
MH  - Platelet Count
MH  - Prospective Studies
MH  - United States
MH  - Viral Load/*genetics
PMC - PMC3100515
EDAT- 2011/05/25 06:00
MHDA- 2011/07/29 06:00
PMCR- 2012/06/15
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
PHST- 2012/06/15 00:00 [pmc-release]
AID - jir192 [pii]
AID - 10.1093/infdis/jir192 [doi]
PST - ppublish
SO  - J Infect Dis. 2011 Jun 15;203(12):1807-14. doi: 10.1093/infdis/jir192.