PMID- 21610139
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20220317
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Print)
IS  - 0022-3751 (Linking)
VI  - 589
IP  - Pt 14
DP  - 2011 Jul 15
TI  - Central efferent pathways for cold-defensive and febrile shivering.
PG  - 3641-58
LID - 10.1113/jphysiol.2011.210047 [doi]
AB  - Shivering is a remarkable somatomotor thermogenic response that is controlled by 
      brain mechanisms. We recorded EMGs in anaesthetized rats to elucidate the central 
      neural circuitry for shivering and identified several brain regions whose 
      thermoregulatory neurons comprise the efferent pathway driving shivering 
      responses to skin cooling and pyrogenic stimulation. We simultaneously monitored 
      parameters from sympathetic effectors: brown adipose tissue (BAT) temperature for 
      non-shivering thermogenesis and arterial pressure and heart rate for 
      cardiovascular responses. Acute skin cooling consistently increased EMG, BAT 
      temperature and heart rate and these responses were eliminated by inhibition of 
      neurons in the median preoptic nucleus (MnPO) with nanoinjection of muscimol. 
      Stimulation of the MnPO evoked shivering, BAT thermogenesis and tachycardia, 
      which were all reversed by antagonizing GABA(A) receptors in the medial preoptic 
      area (MPO). Inhibition of neurons in the dorsomedial hypothalamus (DMH) or 
      rostral raphe pallidus nucleus (rRPa) with muscimol or activation of 5-HT1A 
      receptors in the rRPa with 8-OH-DPAT eliminated the shivering, BAT thermogenic, 
      tachycardic and pressor responses evoked by skin cooling or by nanoinjection of 
      prostaglandin (PG) E2, a pyrogenic mediator, into the MPO. These data are 
      summarized with a schematic model in which the shivering as well as the 
      sympathetic responses for cold defence and fever are driven by descending 
      excitatory signalling through the DMH and the rRPa, which is under a tonic 
      inhibitory control from a local circuit in the preoptic area. These results 
      provide the interesting notion that, under the demand for increasing levels of 
      heat production, parallel central efferent pathways control the somatic and 
      sympathetic motor systems to drive thermogenesis.
FAU - Nakamura, Kazuhiro
AU  - Nakamura K
AD  - Career-Path Promotion Unit for Young Life Scientists, Kyoto University, 
      Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. kazu@cp.kyoto-u.ac.jp
FAU - Morrison, Shaun F
AU  - Morrison SF
LA  - eng
GR  - R01 NS040987/NS/NINDS NIH HHS/United States
GR  - NS40987/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110524
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 0 (Receptors, GABA-A)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 2763-96-4 (Muscimol)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Adipose Tissue, Brown/drug effects/physiology
MH  - Animals
MH  - Blood Pressure/drug effects/physiology
MH  - Body Temperature Regulation/*physiology
MH  - Cold Temperature
MH  - Dinoprostone/pharmacology
MH  - Efferent Pathways/metabolism/*physiology
MH  - Fever/metabolism/*physiopathology
MH  - GABA-A Receptor Antagonists/metabolism
MH  - Heart Rate/drug effects/physiology
MH  - Male
MH  - Mediodorsal Thalamic Nucleus/drug effects/metabolism/physiology
MH  - Medulla Oblongata/drug effects/metabolism/physiology
MH  - Muscimol/pharmacology
MH  - N-Methylaspartate/pharmacology
MH  - Neural Pathways/drug effects/metabolism/physiology
MH  - Neurons/drug effects/metabolism/physiology
MH  - Preoptic Area/drug effects/*metabolism/*physiology
MH  - Raphe Nuclei/drug effects/metabolism/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - Receptors, GABA-A/metabolism
MH  - Shivering/drug effects/*physiology
MH  - Skin Temperature/physiology
MH  - Sympathetic Nervous System/drug effects/metabolism/physiology
MH  - Tachycardia/metabolism/pathology
MH  - Thermogenesis/drug effects/physiology
PMC - PMC3167123
EDAT- 2011/05/26 06:00
MHDA- 2012/04/17 06:00
PMCR- 2012/07/15
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
PHST- 2012/07/15 00:00 [pmc-release]
AID - jphysiol.2011.210047 [pii]
AID - 10.1113/jphysiol.2011.210047 [doi]
PST - ppublish
SO  - J Physiol. 2011 Jul 15;589(Pt 14):3641-58. doi: 10.1113/jphysiol.2011.210047. 
      Epub 2011 May 24.