PMID- 2161036
OWN - NLM
STAT- MEDLINE
DCOM- 19900702
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 161
IP  - 6
DP  - 1990 Jun
TI  - Enhancement of human herpesvirus 6 replication in adult human lymphocytes by 
      monoclonal antibody to CD3.
PG  - 1085-7
AB  - The effect of monoclonal antibody to CD3 on human herpesvirus 6 (HHV-6) 
      replication was assessed in adult peripheral blood mononuclear cells (PBMC) and 
      in cord blood mononuclear cells (CBMC) by anticomplement immunofluorescence and 
      Southern blot hybridization. Infection of CBMC by HHV-6 was productive; however, 
      little or no infection was observed with PBMC from adults exposed to the virus 
      even if stimulated by phytohemagglutinin. Monoclonal antibody to CD3 strongly 
      enhanced HHV-6 replicative cycles in PBMC from adults.
FAU - Kikuta, H
AU  - Kikuta H
AD  - Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
FAU - Lu, H
AU  - Lu H
FAU - Tomizawa, K
AU  - Tomizawa K
FAU - Matsumoto, S
AU  - Matsumoto S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (Antigens, Viral)
RN  - 0 (CD3 Complex)
RN  - 0 (DNA, Viral)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Antibodies, Monoclonal/*immunology
MH  - Antigens, CD/immunology
MH  - Antigens, Differentiation, T-Lymphocyte/*immunology
MH  - Antigens, Viral/biosynthesis
MH  - Blotting, Southern
MH  - CD3 Complex
MH  - DNA, Viral/analysis
MH  - Fetal Blood/microbiology
MH  - Fluorescent Antibody Technique
MH  - Herpesvirus 6, Human/genetics/immunology/*physiology
MH  - Humans
MH  - Lymphocytes/*microbiology
MH  - Receptors, Antigen, T-Cell/*immunology
MH  - Virus Replication
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 10.1093/infdis/161.6.1085 [doi]
PST - ppublish
SO  - J Infect Dis. 1990 Jun;161(6):1085-7. doi: 10.1093/infdis/161.6.1085.