PMID- 2161087
OWN - NLM
STAT- MEDLINE
DCOM- 19900705
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 51
IP  - 4
DP  - 1990 Apr
TI  - Activation of tuberoinfundibular but not tuberohypophysial dopaminergic neurons 
      following intracerebroventricular administration of alpha-melanocyte-stimulating 
      hormone.
PG  - 394-9
AB  - The effect of alpha-melanocyte-stimulating hormone (alpha MSH) on the activity of 
      different central dopaminergic neurons in the male rat was determined by 
      measuring the concentration of 3,4-dihydroxyphenylacetic acid (DOPAC) and the 
      accumulation of 3,4-dihydroxyphenylalanine (DOPA) following the administration of 
      a decarboxylase inhibitor in brain regions that contain terminals of 
      nigrostriatal (striatum), mesolimbic (nucleus accumbens), tuberoinfundibular 
      (median eminence) and tuberohypophysial (neural and intermediate lobe of the 
      pituitary) dopaminergic neurons. Intracerebroventricular (i.c.v.) administration 
      of alpha MSH caused a prompt (within 30 min) increase in the concentration of 
      DOPAC and the accumulation of DOPA in the median eminence, but was without effect 
      in the other brain regions. The alpha MSH-induced increase in tuberoinfundibular 
      dopaminergic neuronal activity was temporally related to a decrease in 
      circulating concentrations of prolactin. Twelve hours after the i.c.v. 
      administration of prolactin DOPA accumulation increased in the median eminence 
      but not in the neural or intermediate lobes of the pituitary. DOPA accumulation 
      was not altered in any brain region 12 h after the i.c.v. administration of alpha 
      MSH. These results suggest that alpha MSH acts acutely to selectively activate 
      tuberoinfundibular dopaminergic neurons and thereby cause the secretion of 
      prolactin from the anterior pituitary to decrease.
FAU - Lindley, S E
AU  - Lindley SE
AD  - Department of Pharmacology and Toxicology, Michigan State University, East 
      Lansing.
FAU - Lookingland, K J
AU  - Lookingland KJ
FAU - Moore, K E
AU  - Moore KE
LA  - eng
GR  - NS-15911/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 581-05-5 (alpha-MSH)
RN  - 63-84-3 (Dihydroxyphenylalanine)
RN  - 9002-62-4 (Prolactin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
EIN - Neuroendocrinology 1990 Aug;52(2):following 211
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Arcuate Nucleus of Hypothalamus/cytology/*drug effects
MH  - Dihydroxyphenylalanine/metabolism
MH  - Dopamine/*physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Median Eminence/cytology/*drug effects
MH  - Neurons/*drug effects
MH  - Pituitary Gland/*drug effects
MH  - Prolactin/blood
MH  - Rats
MH  - alpha-MSH/*pharmacology
EDAT- 1990/04/01 00:00
MHDA- 1990/04/01 00:01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 1990/04/01 00:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 10.1159/000125381 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1990 Apr;51(4):394-9. doi: 10.1159/000125381.