PMID- 21611177
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 5
DP  - 2011
TI  - Structural correlates of taste and smell loss in encephalitis disseminata.
PG  - e19702
LID - 10.1371/journal.pone.0019702 [doi]
LID - e19702
AB  - BACKGROUND: Olfactory dysfunction in MS patients is reported in the literature. 
      MRI of the olfactory bulb (OB) is discussed as a promising new testing method for 
      measuring olfactory function (OF). Aim of this study was to explore reasons for 
      and optimize the detection of olfactory dysfunction in MS patients with MRI. 
      MATERIALS AND METHODS: OB and olfactory brain volume was assessed within 34 MS 
      patients by manual segmentation. Olfactory function was tested using the 
      Threshold-Discrimination-Identification-Test (TDI), gustatory function was tested 
      using Taste Strips (TST). RESULTS: 41% of the MS patients displayed olfactory 
      dysfunction (8% of the control group), 16% displayed gustatory dysfunction (5% of 
      the control group). There was a correlation between the OB volume and the number 
      and volume of MS lesions in the olfactory brain. Olfactory brain volume 
      correlated with the volume of lesions in the olfactory brain and the EDSS score. 
      The TST score correlated with the number and volume of lesions in the olfactory 
      brain. CONCLUSION: The correlation between a higher number and volume of MS 
      lesions with a decreased OB and olfactory brain volume could help to explain 
      olfactory dysfunction.
FAU - Schmidt, Felix Alexander
AU  - Schmidt FA
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Berlin, Charite 
      Campus Mitte, Smell and Taste Consultation Service, Berlin, Germany.
FAU - Goktas, Onder
AU  - Goktas O
FAU - Harms, Lutz
AU  - Harms L
FAU - Bohner, Georg
AU  - Bohner G
FAU - Erb, Katharina
AU  - Erb K
FAU - Dahlslett, Bettina
AU  - Dahlslett B
FAU - Fleiner, Franca
AU  - Fleiner F
LA  - eng
PT  - Journal Article
DEP - 20110517
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Encephalitis/*pathology/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Olfactory Bulb/physiopathology
MH  - Sensory Thresholds/physiology
MH  - Smell/*physiology
MH  - Taste/*physiology
MH  - Young Adult
PMC - PMC3096623
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/05/26 06:00
MHDA- 2011/09/13 06:00
PMCR- 2011/05/17
CRDT- 2011/05/26 06:00
PHST- 2010/12/24 00:00 [received]
PHST- 2011/04/08 00:00 [accepted]
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
PHST- 2011/05/17 00:00 [pmc-release]
AID - PONE-D-11-00372 [pii]
AID - 10.1371/journal.pone.0019702 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(5):e19702. doi: 10.1371/journal.pone.0019702. Epub 2011 May 17.