PMID- 21611835
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20211020
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 36
IP  - 10
DP  - 2011 Oct
TI  - Prenatal amphetamine exposure effects on dopaminergic receptors and transporter 
      in postnatal rats.
PG  - 1740-9
LID - 10.1007/s11064-011-0489-z [doi]
AB  - We investigated the influence of prenatal amphetamine exposure (PAE) on dopamine 
      (DA) receptors, and dopamine transporter (DAT) in various striatal and limbic 
      subregions and locomotor activity induced by novel environmental conditions and 
      amphetamine at two postnatal ages, 35 days old (prepubertal) and 60 days old 
      (postpubertal). Experiments were carried out on pregnant female Sprague-Dawley 
      rats, which were daily injected with either d-amphetamine sulfate (1 mg/kg) or 
      saline solution (0.9%) for 11 days, from gestation day 11-21. In PAE rats 
      compared to control we found the following: at pre-pubertal age, an enhancement 
      of DA D1 in the dorsolateral area of the caudate-putamen (CPu), CPu-ventral and 
      shell of the nucleus accumbens (NAcc) with a decrement of the DA D3 receptors in 
      NAcc, olfactory tubercle (OT), and the islands of Calleja (IoC); whereas at 
      postpubertal age, an increase in the levels of DAT in the NAcc and fundus of the 
      CPu, and OT along with a decrease in the expression of DA D2 receptors only in 
      the NAcc shell were found in PAE rats compared to control. In addition, 
      amphetamine induces a marked decrease in locomotor activity at postpubertal age 
      in rats with PAE. These results suggest a differential effect of amphetamines on 
      the DAT mechanism of the nervous system during embryonic development of animals 
      with implications in behavior and drug addictions at adulthood age.
FAU - Flores, Gonzalo
AU  - Flores G
AD  - Instituto de Fisiologia, Universidad Autonoma de Puebla, 14 Sur 6301, San Manuel, 
      72570 Puebla, CP, Mexico. gflores@siu.buap.mx
FAU - de Jesus Gomez-Villalobos, Maria
AU  - de Jesus Gomez-Villalobos M
FAU - Rodriguez-Sosa, Leonardo
AU  - Rodriguez-Sosa L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110525
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dopamine Agents)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Receptors, Dopamine)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*pharmacology
MH  - Animals
MH  - Autoradiography
MH  - Behavior, Animal/drug effects
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Child
MH  - Child, Preschool
MH  - Corpus Striatum/drug effects/metabolism
MH  - Dopamine Agents/*pharmacology
MH  - Dopamine Plasma Membrane Transport Proteins/*metabolism
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Motor Activity/*drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine/*metabolism
EDAT- 2011/05/26 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/04/26 00:00 [accepted]
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1007/s11064-011-0489-z [doi]
PST - ppublish
SO  - Neurochem Res. 2011 Oct;36(10):1740-9. doi: 10.1007/s11064-011-0489-z. Epub 2011 
      May 25.