PMID- 21612633
OWN - NLM
STAT- MEDLINE
DCOM- 20111026
LR  - 20231105
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11
DP  - 2011 May 25
TI  - Asking the right questions: developing evidence-based strategies for treating HIV 
      in women and children.
PG  - 388
LID - 10.1186/1471-2458-11-388 [doi]
AB  - In July 2010, the World Health Organization (WHO) issued formal revisions of its 
      guidelines on the use of highly active antiretroviral therapy for HIV. The new 
      guidelines greatly expand eligibility for treatment of adults and children, as 
      well as for pregnant women seeking prophylaxis for vertical HIV transmission. 
      WHO's new recommendations bring the guidelines closer to practices in developed 
      countries, and its shift to earlier treatment alone will increase the number of 
      treatment-eligible people by 50% or more.Scaling up access to HIV treatment is 
      revealing important gaps in our understanding of how best to provide for all 
      those in need. This knowledge gap is especially significant in developing 
      countries, where women and children comprise a majority of those living with HIV 
      infection. Given the magnitude and significance of these populations, the 
      International AIDS Society, through its Industry Liaison Forum, prioritized HIV 
      treatment and prophylaxis of women and children. In March 2010, the International 
      AIDS Society and 15 partners launched a Consensus Statement outlining priority 
      areas in which a relative lack of knowledge impedes delivery of optimal 
      prevention of mother to child transmission (PMTCT) and treatment to women and 
      children.The Consensus Statement, "Asking the Right Questions: Advancing an HIV 
      Research Agenda for Women and Children", makes a special appeal for a more 
      gender-sensitive approach to HIV research at all stages, from conception to 
      design and implementation. It particularly emphasizes research to enhance the 
      understanding of sex-based differences and paediatric needs in treatment uptake 
      and response. In addition to clinical issues, the statement focuses on 
      programmatic research that facilitates access and adherence to antiretroviral 
      regimens. Better coordination of HIV management with sexual and reproductive 
      healthcare delivery is one such approach.We discuss here our knowledge gaps 
      concerning effective, safe PMTCT and treatment for women and children in light of 
      the expansion envisioned by WHO's revised guidelines. The guideline's new goals 
      present an opportunity for advancing the women and children's agenda outlined in 
      the Consensus Statement.
FAU - Karim, Quarraisha Abdool
AU  - Karim QA
AD  - Department of Epidemiology, Columbia University, New York, USA.
FAU - Banegura, Anchilla
AU  - Banegura A
FAU - Cahn, Pedro
AU  - Cahn P
FAU - Christie, Celia D C
AU  - Christie CD
FAU - Dintruff, Robert
AU  - Dintruff R
FAU - Distel, Manuel
AU  - Distel M
FAU - Hankins, Catherine
AU  - Hankins C
FAU - Hellmann, Nicholas
AU  - Hellmann N
FAU - Katabira, Elly
AU  - Katabira E
FAU - Lehrman, Sandra
AU  - Lehrman S
FAU - Montaner, Julio
AU  - Montaner J
FAU - Purdon, Scott
AU  - Purdon S
FAU - Rooney, James F
AU  - Rooney JF
FAU - Wood, Robin
AU  - Wood R
FAU - Heidari, Shirin
AU  - Heidari S
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110525
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Antiretroviral Therapy, Highly Active/adverse effects
MH  - Child, Preschool
MH  - Clinical Protocols/standards
MH  - Consensus
MH  - *Evidence-Based Medicine
MH  - Female
MH  - Fetus/drug effects
MH  - Guidelines as Topic
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Infant
MH  - Infectious Disease Transmission, Vertical/prevention & control
MH  - Pregnancy
MH  - World Health Organization
PMC - PMC3118247
EDAT- 2011/05/27 06:00
MHDA- 2011/10/27 06:00
CRDT- 2011/05/27 06:00
PHST- 2010/10/06 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/10/27 06:00 [medline]
AID - 1471-2458-11-388 [pii]
AID - 10.1186/1471-2458-11-388 [doi]
PST - epublish
SO  - BMC Public Health. 2011 May 25;11:388. doi: 10.1186/1471-2458-11-388.