PMID- 2161300
OWN - NLM
STAT- MEDLINE
DCOM- 19900706
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 32
IP  - 4
DP  - 1990 Apr
TI  - The loss of circadian rhythm for intact parathyroid hormone and nephrogenous 
      cyclic AMP in patients with primary hyperparathyroidism.
PG  - 475-83
AB  - The measurement of serum intact parathyroid hormone (PTH) (1-84) over a 24-h 
      period has shown the existence of a circadian rhythm in normal males which is 
      absent in patients with primary hyperparathyroidism. The physiological 
      significance of this observation is reflected in the presence of parallel changes 
      in nephrogenous cyclic adenosine monophosphate (N-cAMP) in normals which are also 
      absent in primary hyperparathyroidism. Serum calcium, adjusted for variations in 
      albumin concentrations, showed a transient fall in normal subjects prior to the 
      nocturnal rise in PTH (1-84). A similar transient fall in serum adjusted calcium 
      was observed in the hyperparathyroid patients. Serum phosphate showed a circadian 
      rhythm in normal subjects, and an attenuated rhythm persisted in primary 
      hyperparathyroidism. These data suggest that both ionic factors and higher 
      centres play important roles in the fine control of PTH (1-84) secretion.
FAU - Logue, F C
AU  - Logue FC
AD  - Institute of Biochemistry, Royal Infirmary, Glasgow, UK.
FAU - Fraser, W D
AU  - Fraser WD
FAU - Gallacher, S J
AU  - Gallacher SJ
FAU - Cameron, D A
AU  - Cameron DA
FAU - O'Reilly, D S
AU  - O'Reilly DS
FAU - Beastall, G H
AU  - Beastall GH
FAU - Patel, U
AU  - Patel U
FAU - Boyle, I T
AU  - Boyle IT
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Phosphates)
RN  - E0399OZS9N (Cyclic AMP)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/blood
MH  - Circadian Rhythm/*physiology
MH  - Cyclic AMP/*blood/urine
MH  - Humans
MH  - Hyperparathyroidism/*blood/urine
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/*blood
MH  - Phosphates/blood
EDAT- 1990/04/01 00:00
MHDA- 1990/04/01 00:01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 1990/04/01 00:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 10.1111/j.1365-2265.1990.tb00888.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 1990 Apr;32(4):475-83. doi: 
      10.1111/j.1365-2265.1990.tb00888.x.