PMID- 21613051
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20210204
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 17 Suppl 3
DP  - 2011 Jul-Aug
TI  - Are microRNAs involved in the endocrine-specific pattern of tumorigenesis in 
      multiple endocrine neoplasia type 1?
PG  - 58-63
LID - 10.4158/EP11062.RA [doi]
AB  - OBJECTIVE: To provide a general background regarding current knowledge about 
      microRNA (miRNA) involvement in endocrine functions and in multiple endocrine 
      neoplasia type 1 (MEN 1) endocrine tumorigenesis. METHODS: A literature search 
      was conducted in the miRNA database for articles on the role of miRNAs in the 
      initiation and progression of human malignant conditions, inasmuch as miRNAs show 
      different patterns of expression in normal and neoplastic tissues. We address the 
      potential role of miRNAs in the endocrine pancreas, the pituitary gland, and the 
      parathyroid glands-areas where MEN 1 shows high penetrance. RESULTS: Experimental 
      studies have shown the involvement of miRNAs in regulation of endocrine 
      functions, such as insulin secretion. Moreover, studies have provided evidence 
      that dysregulation of miRNAs was responsible for endocrine carcinogenesis, 
      including pancreatic, pituitary, and parathyroid tumors. CONCLUSION: miRNA 
      expression profiles may become useful biomarkers for endocrine tumor diagnostics 
      as well as potential targets of therapeutic strategies applied to pathologic 
      conditions such as type 2 diabetes and endocrine tumors. Future studies should 
      investigate the molecular and cellular mechanisms of tissue selectivity in MEN 
      1-associated tumorigenesis, in an effort to develop an RNA-based treatment that 
      could prevent or delay the onset of MEN 1-associated tumors.
FAU - Luzi, Ettore
AU  - Luzi E
AD  - Regional Centre for Hereditary Endocrine Tumors, AOUC, University of Florence 
      Medical School, Florence, Italy.
FAU - Brandi, Maria Luisa
AU  - Brandi ML
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
EDAT- 2011/05/27 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S1530-891X(20)41724-0 [pii]
AID - 10.4158/EP11062.RA [doi]
PST - ppublish
SO  - Endocr Pract. 2011 Jul-Aug;17 Suppl 3:58-63. doi: 10.4158/EP11062.RA.