PMID- 21613053
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20221207
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 17
IP  - 6
DP  - 2011 Nov-Dec
TI  - Low urine calcium excretion in African American patients with primary 
      hyperparathyroidism.
PG  - 867-72
LID - 10.4158/EP11022.OR [doi]
AB  - OBJECTIVE: To evaluate the prevalence of low urine calcium excretion in African 
      American patients with primary hyperparathyroidism (PHPT), a common disorder 
      associated with bone and renal complications, and to assess the distinction 
      between PHPT and familial hypocalciuric hypercalcemia (FHH), a rare benign 
      genetic disease. METHODS: We conducted a retrospective study on a cohort of 1,297 
      patients in whom a 24-hour urine study was performed for measurement of urine 
      calcium and creatinine. PHPT was diagnosed if the serum calcium concentration was 
      >/=10.5 mg/dL and intact parathyroid hormone (PTH) was >/=40 pg/mL. Patients 
      receiving medications that affect urine calcium or with glomerular filtration 
      rate </=30 mL/min were excluded. RESULTS: Ninety-six patients satisfied the 
      diagnostic criteria for PHPT. The African American (n = 70) and non-African 
      American (n = 26) patients did not differ in their mean age, body mass index, 
      glomerular filtration rate, serum PTH, 25-hydroxyvitamin D levels, and 24-hour 
      urine creatinine values. Median values of urine calcium/creatinine (mg/g) were 
      122 for African American versus 214 for non-African American patients (P = .006). 
      Thirty-one of 70 African American patients (44%) had a urine calcium/creatinine 
      ratio </=100 mg/g, whereas only 2 of 26 non-African American patients (8%) had this 
      value (P = .001). CONCLUSION: The prevalence of low urine calcium excretion among 
      African American patients with PHPT is unexpectedly high. A threshold of 100 mg/g 
      urine calcium/creatinine identified 44% of such patients with PHPT as having FHH 
      in this cohort. Therefore, other clinical criteria and laboratory variables 
      should be used to distinguish PHPT from FHH in African American patients with 
      PTH-dependent hypercalcemia.
FAU - Taha, Wael
AU  - Taha W
AD  - Division of Endocrinology, Diabetes and Metabolism, Department of Internal 
      Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, 
      USA. wtaha@med.wayne.edu
FAU - Singh, Neelima
AU  - Singh N
FAU - Flack, John M
AU  - Flack JM
FAU - Abou-Samra, Abdul B
AU  - Abou-Samra AB
LA  - eng
GR  - 5P50ES012395-05/ES/NIEHS NIH HHS/United States
GR  - 5R01DK062286-06/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Parathyroid Hormone)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
RN  - Hypocalciuric hypercalcemia, familial, type 1
SB  - IM
MH  - *Black or African American
MH  - Aged
MH  - Algorithms
MH  - Calcium/blood/*urine
MH  - Cohort Studies
MH  - Creatinine/urine
MH  - Diagnosis, Differential
MH  - Electronic Health Records
MH  - Female
MH  - Humans
MH  - Hypercalcemia/blood/*congenital/epidemiology/ethnology/urine
MH  - Hyperparathyroidism, Primary/blood/diagnosis/ethnology/*urine
MH  - Male
MH  - Michigan/epidemiology
MH  - Middle Aged
MH  - Parathyroid Hormone/blood
MH  - Prevalence
MH  - Retrospective Studies
EDAT- 2011/05/27 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S1530-891X(20)43273-2 [pii]
AID - 10.4158/EP11022.OR [doi]
PST - ppublish
SO  - Endocr Pract. 2011 Nov-Dec;17(6):867-72. doi: 10.4158/EP11022.OR.