PMID- 21613466
OWN - NLM
STAT- MEDLINE
DCOM- 20120420
LR  - 20191210
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 22
IP  - 1
DP  - 2012 Jan
TI  - Distinct patterns of functional and effective connectivity between perirhinal 
      cortex and other cortical regions in recognition memory and perceptual 
      discrimination.
PG  - 74-85
LID - 10.1093/cercor/bhr075 [doi]
AB  - Traditionally, the medial temporal lobe (MTL) is thought to be dedicated to 
      declarative memory. Recent evidence challenges this view, suggesting that 
      perirhinal cortex (PrC), which interfaces the MTL with the ventral visual 
      pathway, supports highly integrated object representations in recognition memory 
      and perceptual discrimination. Even with comparable representational demands, 
      perceptual and memory tasks differ in numerous task demands and the subjective 
      experience they evoke. Here, we tested whether such differences are reflected in 
      distinct patterns of connectivity between PrC and other cortical regions, 
      including differential involvement of prefrontal control processes. We examined 
      functional magnetic resonance imaging data for closely matched perceptual and 
      recognition memory tasks for faces that engaged right PrC equivalently. 
      Multivariate seed analyses revealed distinct patterns of interactions: Right 
      ventrolateral prefrontal and posterior cingulate cortices exhibited stronger 
      functional connectivity with PrC in recognition memory; fusiform regions were 
      part of the pattern that displayed stronger functional connectivity with PrC in 
      perceptual discrimination. Structural equation modeling revealed distinct 
      patterns of effective connectivity that allowed us to constrain interpretation of 
      these findings. Overall, they demonstrate that, even when MTL structures show 
      similar involvement in recognition memory and perceptual discrimination, 
      differential neural mechanisms are reflected in the interplay between the MTL and 
      other cortical regions.
FAU - O'Neil, Edward B
AU  - O'Neil EB
AD  - Department of Psychology, University of Western Ontario, London, Ontario, Canada.
FAU - Protzner, Andrea B
AU  - Protzner AB
FAU - McCormick, Cornelia
AU  - McCormick C
FAU - McLean, D Adam
AU  - McLean DA
FAU - Poppenk, Jordan
AU  - Poppenk J
FAU - Cate, Anthony D
AU  - Cate AD
FAU - Kohler, Stefan
AU  - Kohler S
LA  - eng
GR  - MOP 93644/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110525
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Brain Mapping
MH  - Discrimination, Psychological/*physiology
MH  - Face
MH  - Functional Laterality
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Nerve Net/blood supply/physiology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Pattern Recognition, Visual/*physiology
MH  - Photic Stimulation/methods
MH  - Recognition, Psychology/*physiology
MH  - Temporal Lobe/blood supply/*physiology
MH  - Visual Pathways/blood supply/*physiology
EDAT- 2011/05/27 06:00
MHDA- 2012/04/21 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2012/04/21 06:00 [medline]
AID - bhr075 [pii]
AID - 10.1093/cercor/bhr075 [doi]
PST - ppublish
SO  - Cereb Cortex. 2012 Jan;22(1):74-85. doi: 10.1093/cercor/bhr075. Epub 2011 May 25.