PMID- 2161355
OWN - NLM
STAT- MEDLINE
DCOM- 19900712
LR  - 20191210
IS  - 0029-0661 (Print)
IS  - 0029-0661 (Linking)
VI  - 66
IP  - 3
DP  - 1990 Mar 20
TI  - [Experimental studies on the effects of insulin on central regulation of blood 
      pressure].
PG  - 182-97
AB  - It has been widely revealed that an insulin-like immunoreactive substance (ILI) 
      is distributed in the brain, particularly in the hypothalamus and 
      circumventricular areas where it is supposed that the balances of water and 
      electrolytes are regulated. Although the insulin synthesis of the brain has not 
      been clarified, the existence of ILI in the brain is clearly demonstrated, and 
      ILI may play some important physiological roles on blood pressure regulation as 
      well as feeding behavior. Taking notice of the Na(+)-K+ ATPase activating action 
      of insulin, we aimed to investigate the central cardiovascular effects of insulin 
      using rats, in comparison with the endogenous digoxin-like immunoreactive 
      substance (DLI), which exists in the same sites of ILI, inhibits Na(+)-K+ ATPase 
      activity, and increases blood pressure. When rats were fed high-salt diets for 4 
      weeks, hypothalamic and pituitary contents of ILI decreased significantly 
      compared to those of rats on a regular diet. Intracerebroventricular (i.c.v.) 
      infusion of insulin lowered the femoral arterial pressure and decreased the heart 
      rate significantly in both urethane-anesthetized and conscious rats, and 
      inhibited the renal sympathetic activities in urethane-anesthetized rats. 
      Intravenous infusion of the same amounts of insulin, however, influenced neither 
      blood pressure nor heart rate. Simultaneous i.c.v. infusion of insulin abolished 
      the elevation of both blood pressure and heart rate produced by i.c.v. infusion 
      of hypertonic saline. The increase in the plasma DLI was also abolished 
      significantly. Inhibiting central sympathetic nerve activities and DLI secretion 
      from the hypothalamus, cerebral insulin may effect the central regulations of 
      blood pressure, particularly in salt-loading conditions.
FAU - Nishimura, M
AU  - Nishimura M
AD  - Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of 
      Medicine, Japan.
LA  - jpn
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Nihon Naibunpi Gakkai Zasshi
JT  - Nihon Naibunpi Gakkai zasshi
JID - 0413717
RN  - 0 (Blood Proteins)
RN  - 0 (Cardenolides)
RN  - 0 (Insulin)
RN  - 0 (Saponins)
RN  - 0 (digoxin-like factors)
RN  - 73K4184T59 (Digoxin)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Blood Proteins/metabolism
MH  - Cardenolides
MH  - Depression, Chemical
MH  - *Digoxin
MH  - Heart Rate/*drug effects
MH  - Infusions, Intravenous
MH  - Injections, Intraventricular
MH  - Insulin/administration & dosage/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Saponins
MH  - Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors
EDAT- 1990/03/20 00:00
MHDA- 1990/03/20 00:01
CRDT- 1990/03/20 00:00
PHST- 1990/03/20 00:00 [pubmed]
PHST- 1990/03/20 00:01 [medline]
PHST- 1990/03/20 00:00 [entrez]
AID - 10.1507/endocrine1927.66.3_182 [doi]
PST - ppublish
SO  - Nihon Naibunpi Gakkai Zasshi. 1990 Mar 20;66(3):182-97. doi: 
      10.1507/endocrine1927.66.3_182.