PMID- 21613986
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20110701
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 80
IP  - 2
DP  - 2011 Jul
TI  - Homeostatic and pathogenic role of renal dendritic cells.
PG  - 139-45
LID - 10.1038/ki.2011.129 [doi]
AB  - Dendritic cells (DCs) form a bridge between the innate and adaptive immune 
      systems and fundamentally have an impact on anti-infectious defense and 
      immune-mediated diseases, including those affecting the kidney. The field of 
      renal dendritic cells (rDCs) is rapidly evolving, and work in rodent models has 
      provided the first insight into their functional role in kidney homeostasis and 
      disease. Recent findings indicate that rDCs have an important sentinel role 
      against kidney injury and infection. In acute immune-mediated disease they 
      function in an anti-inflammatory manner, but may acquire pro-inflammatory 
      functionality when renal inflammation becomes chronic. In chronic disease rDCs 
      mature and stimulate rather than tolerize effector T cells, and may contribute to 
      progression of kidney disease. Recent progress in aligning murine and human DC 
      subsets has opened avenues for making knowledge obtained from mechanistic studies 
      in animal models available for better interpretation of kidney biopsies. There is 
      firsthand evidence indicating changes in human DC subsets and their distribution 
      in some kidney diseases. Data are presently lacking on the identity of rDC 
      progenitors, the molecular mechanisms governing their recruitment into the 
      kidney, and the role of rDCs in kidney homeostasis. This review highlights recent 
      findings in the study of rDCs.
FAU - Teteris, Simon A
AU  - Teteris SA
AD  - Institutes of Molecular Medicine and Experimental Immunology, 
      Friedrich-Wilhelms-Universitat Bonn, Bonn, Germany.
FAU - Engel, Daniel R
AU  - Engel DR
FAU - Kurts, Christian
AU  - Kurts C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110525
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
SB  - IM
MH  - Animals
MH  - Dendritic Cells/immunology/*pathology
MH  - Homeostasis/*immunology
MH  - Humans
MH  - Kidney/immunology/pathology
MH  - Kidney Diseases/*immunology/pathology
EDAT- 2011/05/27 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - S0085-2538(15)55013-8 [pii]
AID - 10.1038/ki.2011.129 [doi]
PST - ppublish
SO  - Kidney Int. 2011 Jul;80(2):139-45. doi: 10.1038/ki.2011.129. Epub 2011 May 25.