PMID- 21614094
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20231105
IS  - 2041-4889 (Electronic)
VI  - 2
DP  - 2011 May 26
TI  - Reciprocal influence of the p53 and the hypoxic pathways.
PG  - e164
LID - 10.1038/cddis.2011.48 [doi]
AB  - When cells sense a decrease in oxygen availability (hypoxia), they develop 
      adaptive responses in order to sustain this condition and survive. If hypoxia 
      lasts too long or is too severe, the cells eventually die. Hypoxia is also known 
      to modulate the p53 pathway, in a manner dependent or not of HIF-1 
      (hypoxia-inducible factor-1), the main transcription factor activated by hypoxia. 
      The p53 protein is a transcription factor, which is rapidly stabilised by 
      cellular stresses and which has a major role in the cell responses to these 
      stresses. The aim of this review is to compile what has been reported until now 
      about the interconnection between these two important pathways. Indeed, according 
      to the cell line, the severity and the duration of hypoxia, oxygen deficiency 
      influences very differently p53 protein level and activity. Conversely, p53 is 
      also described to affect HIF-1alpha stability, one of the two subunits of HIF-1, and 
      HIF-1 activity. The direct and indirect interactions between HIF-1alpha and p53 are 
      described as well as the involvement in this complex network of their respective 
      ubiquitin ligases von Hippel Lindau protein and murine double minute 2. Finally, 
      the synergistic or antagonistic effects of p53 and HIF-1 on some important 
      cellular pathways are discussed.
FAU - Sermeus, A
AU  - Sermeus A
AD  - Laboratory of Biochemistry and Cellular Biology (URBC), NARILIS, University of 
      Namur-FUNDP, Namur, Belgium.
FAU - Michiels, C
AU  - Michiels C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110526
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Animals
MH  - Cell Death
MH  - Cell Hypoxia
MH  - Cell Survival
MH  - Humans
MH  - Hypoxia/*metabolism/pathology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Mutation
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
PMC - PMC3122125
EDAT- 2011/05/27 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - cddis201148 [pii]
AID - 10.1038/cddis.2011.48 [doi]
PST - epublish
SO  - Cell Death Dis. 2011 May 26;2:e164. doi: 10.1038/cddis.2011.48.