PMID- 21614177
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20240510
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 11
IP  - 12
DP  - 2010
TI  - 3,4-Methylenedioxymethamphetamine alters left ventricular function and activates 
      nuclear factor-Kappa B (NF-kappaB) in a time and dose dependent manner.
PG  - 4843-63
LID - 10.3390/ijms11124743 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is an illicit psychoactive drug with 
      cardiovascular effects that have not been fully described. In the current study, 
      we observed the effects of acute MDMA on rabbit left ventricular function. We 
      also observed the effects of MDMA on nuclear factor-kappa B (NF-kappaB) activity in 
      cultured rat ventricular myocytes (H9c2). In the rabbit, MDMA (2 mg/kg) alone 
      caused a significant increase in heart rate and a significant decrease in the 
      duration of the cardiac cycle. Inhibition of nitric oxide synthase (NOS) by 
      pretreatment with L-NAME (10 mg/kg) alone caused significant dysfunction in heart 
      rate, systolic pressure, diastolic pressure, duration of relaxation, duration of 
      cardiac cycle, and mean left ventricular pressure. Pretreatment with L-NAME 
      followed by treatment with MDMA caused significant dysfunction in additional 
      parameters that were not abnormal upon exposure to either compound in isolation: 
      duration of contraction, inotropy, and pulse pressure. Exposure to 1.0 mM MDMA 
      for 6 h or 2.0 muM MDMA for 12 h caused increased nuclear localization of NF-kappaB in 
      cultured H9c2 cells. The current results suggest that MDMA is acutely detrimental 
      to heart function and that an intact cardiovascular NOS system is important to 
      help mitigate early sequelae in some functional parameters. The delayed timing of 
      NF-kappaB activation suggests that this factor may be relevant to MDMA induced 
      cardiomyopathy of later onset.
FAU - Tiangco, David A
AU  - Tiangco DA
AD  - Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, 
      USA.
FAU - Halcomb, Sapna
AU  - Halcomb S
FAU - Lattanzio, Frank A Jr
AU  - Lattanzio FA Jr
FAU - Hargrave, Barbara Y
AU  - Hargrave BY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101126
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (NF-kappa B)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 44RAL3456C (Methamphetamine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - L4I4B1R01F (methylone)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/pharmacology
MH  - Methamphetamine/*analogs & derivatives/pharmacology
MH  - Myocytes, Cardiac/*metabolism/pathology
MH  - NF-kappa B/*metabolism
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitric Oxide/metabolism
MH  - Nitric Oxide Synthase/antagonists & inhibitors/metabolism
MH  - Rabbits
MH  - Rats
MH  - Time Factors
MH  - Ventricular Function, Left/*drug effects
PMC - PMC3100831
OTO - NOTNLM
OT  - H9c2
OT  - MDMA
OT  - NF-kB
OT  - cardiac myocytes
OT  - ecstasy
OT  - iNOS
OT  - nuclear
OT  - rabbit
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2010/01/01
CRDT- 2011/05/27 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2010/11/04 00:00 [revised]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2011/05/27 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - ijms11124743 [pii]
AID - ijms-11-04843 [pii]
AID - 10.3390/ijms11124743 [doi]
PST - ppublish
SO  - Int J Mol Sci. 2010;11(12):4843-63. doi: 10.3390/ijms11124743. Epub 2010 Nov 26.