PMID- 21615853
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20220309
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 109
IP  - 1
DP  - 2012 Jan
TI  - Trends in adverse events of benign prostatic hyperplasia (BPH) in the USA, 1998 
      to 2008.
PG  - 84-7
LID - 10.1111/j.1464-410X.2011.10250.x [doi]
AB  - OBJECTIVE: To determine if the adverse events (AEs) of benign prostatic 
      hyperplasia (BPH) have declined in tandem with increased use of oral therapy. 
      MATERIALS AND METHODS: We used the Nationwide Inpatient Sample, a 20% sample of 
      USA community hospitals, weighted to estimate national numbers to characterize 
      the prevalence of AEs of BPH from 1998 to 2008. We calculated the age-adjusted 
      prevalence of BPH and associated conditions and analyzed prevalence trends with 
      regression modelling. RESULTS: Of 134 million estimated eligible discharges 
      during the study period, 7,464,730 (5.6%) had either a primary or secondary 
      diagnosis of BPH. The age-adjusted prevalence of BPH among all hospitalizations, 
      irrespective of primary diagnosis, increased from 4.3% to 8% (P < 0.001) during 
      the study period. The age-adjusted prevalence of BPH as a primary diagnosis 
      decreased from 0.88% to 0.48% (P < 0.001). Discharges for BPH surgery decreased 
      51% (odds ratio [OR] 0.49, 95% confidence interval [CI] 0.45-0.54, P-trend 
      <0.001) over time. Discharges for primary BPH with acute renal failure increased 
      >400% (OR 4.28, 95% CI 3.22-5.71, P-trend <0.001). There were no significant 
      changes in discharges for primary BPH with urinary retention (P-trend = 0.636), 
      bladder stones (P-trend = 0.117), or urinary infection (P-trend = 0.101) over 
      time. CONCLUSIONS: Increased hospitalizations for BPH with acute renal failure 
      and stable hospitalizations for other AEs of BPH indicate that severe AEs of BPH 
      persist despite widespread use of oral therapies in the USA. Further studies are 
      needed to explain these trends.
CI  - (c) 2011 THE AUTHORS. BJU INTERNATIONAL (c) 2011 BJU INTERNATIONAL.
FAU - Stroup, Sean P
AU  - Stroup SP
AD  - University of California San Diego (UCSD), Division of Urology, San Diego, CA 
      92103-8897, USA.
FAU - Palazzi-Churas, Kerrin
AU  - Palazzi-Churas K
FAU - Kopp, Ryan P
AU  - Kopp RP
FAU - Parsons, J Kellogg
AU  - Parsons JK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110526
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Follow-Up Studies
MH  - Hospitalization/*trends
MH  - Humans
MH  - Inpatients/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Prostatic Hyperplasia/*complications/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - United States/epidemiology
MH  - Urinary Retention/diagnosis/*epidemiology/etiology
EDAT- 2011/05/28 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1464-410X.2011.10250.x [doi]
PST - ppublish
SO  - BJU Int. 2012 Jan;109(1):84-7. doi: 10.1111/j.1464-410X.2011.10250.x. Epub 2011 
      May 26.