PMID- 2161698
OWN - NLM
STAT- MEDLINE
DCOM- 19900717
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 513
IP  - 1
DP  - 1990 Apr 9
TI  - Effects of corticotropin-releasing factor (CRF) and opiates on amphibian 
      locomotion.
PG  - 94-100
AB  - Male rough-skinned newts (Taricha granulosa) were used as a model for the study 
      of the neuroendocrine regulation of locomotion. Intracerebroventricular (i.c.v.) 
      injections of nanogram quantities of corticotropin-releasing factor (CRF) 
      dose-dependently increased locomotion as measured in a circular open-field test 
      arena. In other studies animals received intraperitoneal (i.p.) injections of 
      saline or naloxone, a synthetic opioid antagonist, followed by i.c.v. injections 
      of saline or CRF. With 1-min intervals between injections, neither i.p. saline 
      nor naloxone injections modified the stimulatory effects of CRF injections on 
      locomotor activity. In contrast, with 20-min intervals between injections, the 
      naloxone-plus-CRF injected newts displayed more locomotor activity than the 
      saline-plus-CRF injected newts, suggesting that the opioid system modulated the 
      behavioral effects of CRF. An i.p. injection of bremazocine, an opiate 
      kappa-receptor agonist, suppressed spontaneous locomotion but not CRF-induced 
      locomotion. In contrast, an i.p. injection of morphine, an opiate mu-receptor 
      agonist, did not affect spontaneous locomotion but reduced CRF-induced 
      locomotion, indicating further that the opioid system may modulate the behavioral 
      effects of CRF in this amphibian. The present study provides the first evidence 
      that both CRF and opioids may be involved in the regulation of amphibian 
      locomotor activity.
FAU - Lowry, C A
AU  - Lowry CA
AD  - Department of Zoology, Oregon State University, Corvallis 97331.
FAU - Deviche, P
AU  - Deviche P
FAU - Moore, F L
AU  - Moore FL
LA  - eng
GR  - R01 HD13508/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Benzomorphans)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 0 (Receptors, Opioid, mu)
RN  - 36B82AMQ7N (Naloxone)
RN  - 76I7G6D29C (Morphine)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - ISF76M2DBE (bremazocine)
SB  - IM
MH  - Animals
MH  - Benzomorphans/pharmacology
MH  - Corticotropin-Releasing Hormone/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Locomotion/*drug effects
MH  - Male
MH  - Morphine/pharmacology
MH  - Naloxone/pharmacology
MH  - Receptors, Opioid/drug effects/*physiology
MH  - Receptors, Opioid, kappa
MH  - Receptors, Opioid, mu
MH  - Salamandridae/*physiology
EDAT- 1990/04/09 00:00
MHDA- 1990/04/09 00:01
CRDT- 1990/04/09 00:00
PHST- 1990/04/09 00:00 [pubmed]
PHST- 1990/04/09 00:01 [medline]
PHST- 1990/04/09 00:00 [entrez]
AID - 0006-8993(90)91093-V [pii]
AID - 10.1016/0006-8993(90)91093-v [doi]
PST - ppublish
SO  - Brain Res. 1990 Apr 9;513(1):94-100. doi: 10.1016/0006-8993(90)91093-v.