PMID- 21617887
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20211020
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 93
IP  - 6
DP  - 2011 Jun
TI  - Single versus multiple dose intravenous immunoglobulin in combination with LED 
      phototherapy in the treatment of ABO hemolytic disease in neonates.
PG  - 700-703
LID - 10.1007/s12185-011-0853-4 [doi]
AB  - Intravenous immunoglobulin (IVIG) has been found to decrease hemolysis in 
      neonatal jaundice due to blood group incompatibility, but a consensus on its 
      usage has not been reached. We conducted a study to compare single versus 
      multiple dose of IVIG in combination with light emitting diode (LED) phototherapy 
      in patients with neonatal jaundice secondary to ABO blood incompatibility, and 
      compared the efficacy of these treatments with that in a group of patients who 
      received LED phototherapy solely. Thirty-nine term neonates with ABO blood group 
      incompatibility were enrolled in the study. Group I received one dose of IVIG (1 
      g/kg) and LED phototherapy, and group II two doses of IVIG (1 g/kg) and LED 
      phototherapy, whereas group III received LED phototherapy only. In group I, 
      exchange transfusion was performed in one patient (6%) and in group II in one 
      patient (10%). In the control group, none of the patients required exchange 
      transfusion. Duration of LED phototherapy was 4.3 +/- 0.7 days in group I + II 
      (IVIG group), 3.9 +/- 0.6 days in group III (P = 0.06). Lowest hematocrit level in 
      group I + II was 35.0 +/- 7.8 and group III was 38.9 +/- 4.2, this was statistically 
      significant (P = 0.034). IVIG therapy, single or multiple, did not affect 
      exchange transfusion, need of erythrocyte transfusion and hospitalization time 
      when used in combination with LED phototherapy in the treatment of ABO hemolytic 
      jaundice in neonates.
FAU - Demirel, Gamze
AU  - Demirel G
AD  - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, 
      Altindag, Ankara, Turkey. kgamze@hotmail.com.
FAU - Akar, Melek
AU  - Akar M
AD  - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, 
      Altindag, Ankara, Turkey.
FAU - Celik, Istemi Han
AU  - Celik IH
AD  - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, 
      Altindag, Ankara, Turkey.
FAU - Erdeve, Omer
AU  - Erdeve O
AD  - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, 
      Altindag, Ankara, Turkey.
FAU - Uras, Nurdan
AU  - Uras N
AD  - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, 
      Altindag, Ankara, Turkey.
FAU - Oguz, Serife Suna
AU  - Oguz SS
AD  - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, 
      Altindag, Ankara, Turkey.
FAU - Dilmen, Ugur
AU  - Dilmen U
AD  - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, 06230, 
      Altindag, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20110525
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Blood Transfusion, Autologous
MH  - Erythroblastosis, Fetal/drug therapy/*therapy
MH  - Erythrocyte Transfusion
MH  - Exchange Transfusion, Whole Blood
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Immunologic Factors/*administration & dosage
MH  - Infant
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal
MH  - Jaundice, Neonatal/therapy
MH  - Male
MH  - *Phototherapy
EDAT- 2011/05/28 06:00
MHDA- 2011/10/20 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/01/20 00:00 [received]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/04/04 00:00 [revised]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 10.1007/s12185-011-0853-4 [pii]
AID - 10.1007/s12185-011-0853-4 [doi]
PST - ppublish
SO  - Int J Hematol. 2011 Jun;93(6):700-703. doi: 10.1007/s12185-011-0853-4. Epub 2011 
      May 25.