PMID- 21619467
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20191210
IS  - 1862-278X (Electronic)
IS  - 0013-5585 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Jun
TI  - Non-invasive assessment of cardiac output during mechanical ventilation - a novel 
      approach using an inert gas rebreathing method.
PG  - 147-51
LID - 10.1515/BMT.2011.014 [doi]
AB  - Measurement of cardiac output (CO) is of importance in the diagnostic of 
      critically ill patients. The invasive approach of thermodilution (TD) via 
      pulmonary artery catheter is clinically widely used. A new non-invasive technique 
      of inert gas rebreathing (IGR) shows a good correlation with TD measurements in 
      spontaneously breathing individuals. For the first time, we investigated whether 
      IGR can also be applied to sedated and mechanically ventilated subjects with a 
      clinical point of care device. CO data from IGR were compared with TD in six 
      healthy mongrel dogs. Data sampling was repeated under baseline conditions (rest) 
      and under stress challenge by applying 10 mug/kg/min of dobutamine intravenously. 
      Switching from mechanical ventilation to IGR, as well as the rebreathing 
      procedures, were carried out manually. Cardiac output data from IGR and TD 
      correlated with a coefficient of r=0.90 (95% confidence interval [0.81; 0.95]). 
      The Bland-Altman analysis showed a bias of 0.46 l/min for the IGR CO 
      measurements. Ninety-five percent of all differences fall in the interval [-1.03; 
      1.95], being the limit of the +/- 1.96 standard deviation lines. IGR is a new 
      approach for non-invasive cardiac output measurement in mechanically ventilated 
      individuals, but requires further investigation for clinical use.
FAU - Nickl, Werner
AU  - Nickl W
AD  - University of Witten/Herdecke and HELIOS-Klinikum Wuppertal, Germany.
FAU - Bugaj, Till
AU  - Bugaj T
FAU - Mondritzki, Thomas
AU  - Mondritzki T
FAU - Kuhlebrock, Kathrin
AU  - Kuhlebrock K
FAU - Dinh, Winfried
AU  - Dinh W
FAU - Krahn, Thomas
AU  - Krahn T
FAU - Sohler, Florian
AU  - Sohler F
FAU - Truebel, Hubert
AU  - Truebel H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110527
PL  - Germany
TA  - Biomed Tech (Berl)
JT  - Biomedizinische Technik. Biomedical engineering
JID - 1262533
RN  - 0 (Noble Gases)
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Anesthesia, Closed-Circuit/*instrumentation
MH  - Animals
MH  - Breath Tests/*instrumentation
MH  - Carbon Dioxide/*analysis
MH  - Cardiac Output/*physiology
MH  - Diagnosis, Computer-Assisted/instrumentation/*methods
MH  - Dogs
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - Monitoring, Physiologic/*instrumentation
MH  - Noble Gases/analysis
MH  - Respiration, Artificial/*instrumentation
EDAT- 2011/05/31 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1515/BMT.2011.014 [doi]
PST - ppublish
SO  - Biomed Tech (Berl). 2011 Jun;56(3):147-51. doi: 10.1515/BMT.2011.014. Epub 2011 
      May 27.