PMID- 21622173
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20220225
IS  - 2768-6698 (Electronic)
IS  - 2768-6698 (Linking)
VI  - 16
IP  - 6
DP  - 2011 Jun 1
TI  - Dramatic improvement of DC-based immunotherapy against various malignancies.
PG  - 2233-42
AB  - Dendritic cells (DCs) play a crucial role in maintaining the immune system. 
      Though DC-based cancer immunotherapy has been suggested as a potential treatment 
      for various kinds of malignancies, clinical efficacies are still insufficient in 
      many human trials. To identify the causes of the low efficacies, we paid 
      attention to their numbers and how they are activated. We proved that DCs' 
      antitumor effect depends on their number and the way they are activated. We here 
      established a possible breakthrough, a simple cytokine-based culture method to 
      realize a log-scale order of functional murine/human DCs. Moreover, we 
      demonstrated that DCs activated by replication-deficient recombinant Sendai virus 
      (rSeV) were dramatically more effective than that seen in the use of current DC 
      vaccine for immunotherapy against malignancies. Our study could overcome these 
      problems and would improve treatment of malignancies.
FAU - Harada, Yui
AU  - Harada Y
AD  - R and D Laboratory for Innovative Biotherapeutics, Kyushu University Graduate 
      School of Pharmaceutical Sciences, Fukuoka 812-8582, Japan.
FAU - Yonemitsu, Yoshikazu
AU  - Yonemitsu Y
LA  - eng
PT  - Journal Article
DEP - 20110601
PL  - Singapore
TA  - Front Biosci (Landmark Ed)
JT  - Frontiers in bioscience (Landmark edition)
JID - 101612996
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Cancer Vaccines/administration & dosage/therapeutic use
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Dose-Response Relationship, Immunologic
MH  - Humans
MH  - Immunotherapy, Adoptive/*methods/trends
MH  - Melanoma, Experimental/immunology/therapy
MH  - Mice
MH  - Models, Immunological
MH  - Neoplasms/*immunology/*therapy
EDAT- 2011/05/31 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - 3850 [pii]
AID - 10.2741/3850 [doi]
PST - epublish
SO  - Front Biosci (Landmark Ed). 2011 Jun 1;16(6):2233-42. doi: 10.2741/3850.